Hi, i am pregnant 14 weeks and i am on 100mg imuran that is similar to 6pm, i am doing very well, crohn's is in remission. My doc tor did his thesis on imuran and pregnancy and he told me that it is safety to stay on the medication even in a high dose, there is a risk to come off the medication and have a bad flare up. It is very important you look after yourself before conception. I was on homeopath remedies over a year, which gave me positive results in relation to my crohn's and psoriase. Now i have a very balanced diet with lots of fruits and vegetables and i exercise three to four times a week (pilatos and yoga). Next week i will have an appointment with obs to discuss the possibility of change my medication, because i would like breastfeeding, imuran is toxic "no breastfeeding". I did a lot of research about imuran and pregnancy and many women here were in this drug while pregnant and had health babies. I had my first scan last week, my baby is doing very well, he is healty. I hope my post can help you to decide what is best for you and baby. Of course the best would be no medication at all, but in my case it was not possible , i have three strictures and one of them is very tight. If my crohn's flares could be a disaster. Thanks God everthing is perfect fine, i never been so health as i am now. My pregnancy is doing miracles. All the best, good luck in your decision.