Welcome to Healing Well, kelliej! I am sorry that both you and your daughter are dealing with chronic diseases. I know how difficult it is to watch one's child deal with a serious medical problem. <<Hugs>> I have three autoimmune diseases myself so understand the prednisone rollercoaster issue. I have avascular necrosis in the top of both femurs, most likely from one of my many stints on prednisone to treat my asthma. I face double hip replacements in the future because of this.
What beside prednisone has your daughter been taking for her Crohn's? Your reference to possible Lymphoma from CD meds refers to Remicade and Humira. Both of these meds are biologic category meds.
Some GIs work from the "bottom up", starting with things like Entocort, Pentasa, Asacol or Sulfasalazine. Then if those don't maintain relief of symptoms, some GIs try flagyl or Cipro, both antibiotics. Then comes the immunomodulators like azathioprine (Imuran, Azasan) and 6-mercaptopurine (6-MP, Purinethol). Then the last tier is the biologic category of drugs like Cimzia, Remicade and Humira and Tysabri.
Other GIs prefer the "top-down" approach to threating Crohn's. They start with the biologics in hope of a quick remission. If a patient has severe Crohn's or fistulizing disease, it is more likely that the GI will recommend starting with the biologics.
I have not heard of anyone being prescribed cytoxan as a treatment for CD. However, that doesn't mean it hasn't been done. Your descript
ion of your treatment with cytoxan to "shut down" your immune system is similar to the thought behind the prescribing of azathioprine and 6-MP. Imuran helps modulate the immune system, making it act more normally. In my case, my white count was really high even though I never had an infection. Once I got on Imuran, my WBC is in the normal range. Oddly, I get fewer colds, and viruses too.
Again, welcome to our community. ~~Ides
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.