Anyone flare before their remicade infusion?

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Regular Member

Date Joined Jul 2008
Total Posts : 113
   Posted 12/11/2008 10:42 AM (GMT -7)   
I was just wondering if anyone else has experienced what I have...I will be going for my second remicade infusion tomorrow (already had the 3 loading doses months ago) and last time and this time i end up going to the bathroom more, having more diarreah, more blood, more mucus, and more pain about 2 weeks before my infusion...i'm on a 6 week interval right now and my doctor is actually upping my dosage tomorrow, so maybe it will "last longer"...i'm just not really if it's the remicade wearing off slowly or what...any input would be helpful!!!! thanks :)
21 year old female
Diagnosed with Moderate to Severe Crohn's August 2008 (hospitalized for over a month right after)
Taking...canasa, rowasa, 6mp, aciphex, and Remicade every 6 weeks
As needed...zofran, lortab, tylenol 3, bentyl
Off of Prednisone!!!

Veteran Member

Date Joined Feb 2003
Total Posts : 1811
   Posted 12/11/2008 4:11 PM (GMT -7)   
Yes, my remicade used to weqar off before my next infusion and I would flare. I took months for my doc to believe me/get it approved through insurance and so she would try to "hold me over" by boosting my prednisone for weeks. I was furious. But remicade was new for Crohn's back then. Your doc might have you wait since he is upping the dose for your next infusion, but you are very wise to make note of it. You need to see if it holds you this time or if it still wears off. You might need your infusions closer together - or the higher dose - which you are going to get soon! I hope it does the trick!!!

Veteran Member

Date Joined Jul 2005
Total Posts : 733
   Posted 12/11/2008 4:23 PM (GMT -7)   
I had similar problems when I started to try to "space out" my infusions. We tried upping my dosage, but it didn't work for me - it made me feel like I had been hit by semi truck. What finally ended up working for me was to get the infusions every 4 weeks for 6 months until I was "healed"... that kept me from flaring and then I was eventually able to go every 8+ weeks in between.
27f, dx'd CD July '05 after 6 fistula/abscess surgeries
(miscarried at 13 weeks, now waiting to heal before trying again)
Stopped Humira August 22nd, 2008.
Went Gluten-Free, noticing some definite improvement.
Started LDN October 27th, and already LOVING IT.

"Our greatest fear is not that we are inadequate, but that we are powerful beyond measure."

Veteran Member

Date Joined Oct 2005
Total Posts : 1250
   Posted 12/12/2008 3:56 AM (GMT -7)   
I used to flare right before my next infusion. I am now at the max dose of 10mg/kg every 4 weeks. It has been this way for 1 year and has worked for me. Good luck to you! Blessings, Julie
Diagnosed with Crohn's March 2006, Fibromyalgia November 2008
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 12 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg as needed (for anxiety attacks)

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