side effects of 6mp ( Mercapturine ) on children ?

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New Member

Date Joined Jan 2009
Total Posts : 2
   Posted 1/2/2009 8:11 AM (GMT -7)   
 My 10 yr old daughter was on 6mp ( mercapturine ) for 11 months. She has mild crohn's disease.
 She was just diagnosed with CVID ( common immune variable def ) which she will need IVIG transfusions for life. This medicine was given off label , never any studies for children and advised for 8 week treatment . Basically , this medicine lowered her white blood count where she lost 2/3 of her immunity. Has anyone neen on 6mp ( adult or child) for a long amount of time.. and had any ( any) side effects ?

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 1/2/2009 11:40 AM (GMT -7)   
Hi mothertiger and welcome to Healingwell! Sorry to hear your little one has this darn disease. I was on 6mp for awhile and never had any side effects from it, other than some hairloss. Hopefully someone with more info will be along soon.
Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Veteran Member

Date Joined Mar 2008
Total Posts : 1202
   Posted 1/4/2009 9:43 PM (GMT -7)   
Mine has been on 6mp since spring(April, I think). It allowed her to get off Pred., but I am not sure yet if it is working. It's been so bad for so long. No real side affects, other than hair loss. Dose is alternating 50 then 75 mg., and she has had many blood tests to ensure she metabolizes it properly. That number has jumped up and down over the time she has been on it for no apparent reason. It takes 3-6 monthss just to reach the therapeutic levels.
For some it works miracles though, so just make sure you are closely monitoring it and taking the blood tests on schedule.
Good luck
Daughter,15 diagnosed 1-08 w/ UC .
Asacol, Prevacid, Flagyl, Prednisone 50mg, major flare, now off!, Hosp. four x this yr. Low residue diet still, an
6MP, Colazal ,horrible acne/moon for awhile- No more Pred,but 6mp isn't working. Cortifoam enemas 4xweek
Trying probiotics, Niferex, fish oil, and Mangosteen for kicks.
Had 4th infusion of Remicade(12-08), and still on all of the other drugs, except Flagyl and Pred. Better, no remission. In a drug trial for children. Living on a flare's edge.

Veteran Member

Date Joined Oct 2004
Total Posts : 3042
   Posted 1/5/2009 4:24 AM (GMT -7)   
Hi I was on Imuran it is a 6mp drug and I had no-side effects. i have been off it for awhile now.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital

in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.

My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
Also diagnosed with Osteoarthritis and Rheumatoid Arthritis

Mormor Vicky
Veteran Member

Date Joined Mar 2007
Total Posts : 684
   Posted 1/5/2009 11:09 AM (GMT -7)   
I was on 6-mp for only a couple of months before I suffered real immune problems. My doctor didn't catch it and I ended up in isolation for 11 days because of bone marrow suppression. My recommendation is to make sure your doctor is on top of your situation.
Vicky / 48 years old
DX'd with Crohn's during a resection August 2006
DX'd with Steriod induced Diabetes November 2006
Considered in Clinical remission but have minor signs of disease activity
Daughter (27) also has Crohn's since she was 12.
Currently on 4000mg of Pentasa only for Crohn's
No longer able to take 6-MP because of Bone-Marrow Suppression
Cymbalta, Metformin, Lipitor

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