I too have bad reactions to every crohn's medicine out there, except Remicade. I was on it for YEARS, and it just eventually stopped working, but it really was a savior for me for a long time.
At my first infusion I was running a slight fever. I was premedicated with Tylenol, the fever went down, and we commenced. I started to feel a little short of breath, so they slowed the infusion and gave me some benadryl capsules. I almost immediately went from nervous to sleepy, and they finished the infusion without any other mishaps. I continued treatments, usually feeling tired the day of the infusion and often the day after, but that was really the worst of it. At my request, I switched to IV benadryl for premedication, and would be injected with it immediately before they started my infusions. I found that the IV benadryl kicked in faster and wore off faster, which calmed my nerves AND allowed me drive myself home without being drowsy. I never once went without being premedicated with benadryl, so I don't know if I even really needed it... it was just standard practice there I guess. My kidneys(middle back) would hurt a little bit three or four days in, but I found that chugging lots of Gatorade before and after my infusions helped alleviate that.
All in all, I really loved the stuff. I referred to it fondly as my "mouse juice". I only stopped it because of a health insurance mishap that caused my treatment to be delayed for several months. By the time I went back and got my infusion, it didn't do any good. It didn't do anything bad, it just didn't work like it used to.
I know it's scary, and you have every right to be nervous... Remicade is serious business. But, it also has the potential to greatly improve your quality of life. Relax, think good thoughts, and give it a chance. It might be magic "mouse juice" for you too.
27f, dx'd CD July '05 after 6 fistula/abscess surgeries
(miscarried at 13 weeks, now waiting to heal before trying again)
Stopped Humira August 22nd, 2008.
Went Gluten-Free, noticing some definite improvement.
Started LDN October 27th, and already LOVING IT.
"Our greatest fear is not that we are inadequate, but that we are powerful beyond measure."