Easier2Run, it's something that you will have to decide, as difficult as that is. Like patientspiders said, it's what you are comfortable with. I have no problem taking biologicals. I tried Pentasa and 6-mp previously and nothing seemed to work until we got to the biologicals. Remicade, Cimzia and Humira put me into remission and have kept me there and I don't know what I would do without them. But, it's something you have to decide based on what you are comfortable with and can afford. The pills are usually much cheaper, so a lot of people have to try them first and not get good results in order to get insurance to cover the biologicals.