I recently participated in the phase 2b trial for Ustekinumab for Crohn's, and unfortunately the results were dismal. I have had Crohn's (Crohn's colitis) for more than 15 years and over that time have tried and lost response to just about every course of treatment (Flagyl, Cipro, 6MP, Canasa, local cortizones, Remicade, Humira) and therefore elected to participate in the trail. Sadly, while Ustekinumab is being touted as the 'next big thing', my experience with it was entirely unsuccessful.
I had a severe reaction to the treatment: A few days after receiving the infusion (which we assume must have contained medicine), I had shaking chills, heavy night sweats and worsening symptoms. This lasted for about two weeks and we were able to reduce the chills with acetaminophen every 4 hrs. I needed to use the restroom 8-10 times a day and had little to no warning before needing to find one. Needless to say, we opted to discontinue my participation in the trial and I'm now on 45mg of Prednisone daily and showing improvement.