I get swollen ankles during a Crohn's flare and I'm not on 6MP or Asacol. See my response to TEXAN WITH CROHN'S "Bloodwork" post. It's possible your daughter is suffering from some arthritis.
I always think of swollen body things like this: Crohn's is an inflammatory, auto-immune illness. We all know Crohn's goes beyond our intestinal tract and causes "EXTRA-intestinal" problems. When anything swells or becomes inflamed, it could simply be due to the Crohn's Disease. For example, I occasionally have breathing problems where I can't get a deep breath. X-rays have shown the bronchioles in my lungs to have inflammation during these breathing spells. So doctors automatically wanted to put me on a drug for asthma. I don't have asthma. I was flaring when I couldn't breathe and a Pulmonary Function Test came back fine as far as how my lungs were functioning. So when Crohn's is active, I am of the opinion that ANYTHING AND EVERYTHING can flare.
I've also had very painful back spasms during a flare...around the shoulder blade (bursitis) and in my lower back. I was given pain patches to stick to my body for that. It was like electric shocks going through my back! The tendons and muscles were just INFLAMED.
It, of course, could certainly be a side effect from the drug, too, though. I beginning to get negative about doctors and what they REALLY know about Crohn's. I think it should be mandatory for ALL Gastroenterologists to get together every year and get their stories straight about what IS and ISN'T! :) It's a frustrating illness.
Diagnosed in October, 2004 at age 32.
Current Rx's: Colazal (generic), Omeprazole, Ferrous Sulfate, Librax, One-A-Day multivitamin, Probiotic, Omega-3 Fish Oil, Vitamin D, Vitamin A, Calcium-Magnesium-Zinc, Cranberry pills
Secondary conditions: mouth ulcers, joint pain, swelling ankles, extreme fatigue
Previous/occasional Rx's: 20mg Prednisone taper, Flagyl, Levaquin
No surgeries to date