How fast does prednisone work

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Regular Member

Date Joined Apr 2007
Total Posts : 28
   Posted 2/11/2009 5:25 PM (GMT -7)   
I haven't been on prednisone for a while and I can't remember how fast it typically takes to kick in.  I was on 50 mg for a week and am on day #3 at 45 mg. I still have bad cramping before each BM and haven't seen a ton of results. I seem to remember prednisone working faster in the past.  Can anyone tell me if they have had similar results and if prednisone has taken a bit longer to kick in? 

Veteran Member

Date Joined Apr 2008
Total Posts : 1753
   Posted 2/11/2009 5:49 PM (GMT -7)   
It took about 30 minutes to kick in. 4 months of barely being able to walk or eat and I was out in town and eating sushi.
20 years old, Diagnosed with moderate to severe Crohn's and Colitis in May of 2008.
Currently taking:
Prednisone 5 mg, pentasa 2 pills 4x a day, bentyl as needed, omeprazole in the morning, prenatal multivitamin, humira every other week, and good probiotics.
Surgery for ectopic pregnancy most likely the result of severe Crohn's inflammation in July of 2008.
Attempting a diet without refined sugars, high fat content, bleached or bromated flour, most dairy, red meat, and avoiding anything spicy like the plague. Also refuse to eat anything with trans fat or high fructose/corn syrup.
"He who has a why to live for can bear with almost any how."

Veteran Member

Date Joined Oct 2008
Total Posts : 1343
   Posted 2/11/2009 6:30 PM (GMT -7)   
When I first started it, I was like Lisa. It kicked in the same day I took it. The last time I had prednisone (a couple years ago), it never did help. It was kind of scary, because I always thought I could fall back on prednisone if I needed it. After 3 or 4 months and no results, my insurance finally approved entocort, and that got me on track.

Veteran Member

Date Joined Mar 2005
Total Posts : 1289
   Posted 2/11/2009 9:14 PM (GMT -7)   
i just started taking 60 mg again last day felt better...BUT now i'm down to 50 this week and not feeling so good anymore...not sure why the 10 mg is making such a big difference this time, but blood's back already and pain etc. too...great...

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 2/12/2009 7:30 AM (GMT -7)   
Usually the Pred kicks in by the next day for me, luckily never had it not work.

mtgman, maybe you need to go back up 5mg. Could be the 10mg drop was just too quick for you. My GI tells me when I go down, if I start feeling bad again, to go back up.

Good luck,
Gail *Nanners*
Gail*Nanners* Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Regular Member

Date Joined Apr 2007
Total Posts : 28
   Posted 2/12/2009 8:38 AM (GMT -7)   

thanks for the updates.  I know when my crohn's was mild it kicked in very quickly but now my crohn's is much more severe so maybe it just needs a little more time....hopefully.  I bumped back up to 50mg this morning and we'll see what happens.  I have tried almost every other med so i'm at the end of the line in terms of options.  My GI is hoping this will kick me into remission and then I am possibly going to try Cimzia as maintenance.  Humira didn't work for me but maybe Cimzia will.

Thanks everyone

Veteran Member

Date Joined Mar 2005
Total Posts : 1289
   Posted 2/12/2009 4:25 PM (GMT -7)   
thanks Gail...i will DEFINITLY give that a shot...i feel like crap after dropping 10...maybe it was too fast this time...

Regular Member

Date Joined Sep 2008
Total Posts : 457
   Posted 2/13/2009 4:46 AM (GMT -7)   
My last flare it took almost 3 weeks before I felt better. That is odd for me but at least now I know what to expect next time. Good luck and I hope you feel better soon.

dx'd with Crohns 1984, I was in remission for 12 years
Bowel Resection surgery 2006, Now weaning off  Predisone after another flare. Started taking my Asacol again.

Regular Member

Date Joined Apr 2007
Total Posts : 28
   Posted 2/13/2009 8:56 AM (GMT -7)   

thanks Elizabeth. While I never like to hear people are sick and needing prednisone, it does give me some reassurance that there is still hope the prednisone will kick in soon and i'll start feeling better. I bumped back up to 50mg until I start feeling better.

Good luck as well.


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