I took mtx for a total of about 20 weeks. I had to take a month long break after 10 weeks for gall bladder surgery. I was taking 15mg a week. At first I did ok except for mild nausea the next day so I gradually upped my folic acid until I was eventually taking 4 mg a day. After I had the surgery I went back on mtx and once again, did ok, starting out with 4 mg folic acid. I no longer had the feeling of malaise that I complain about (probably my worst sympton since my gut seems to be doing well on pentasa) and I felt my gut was even better, but it had done nothing for my joints. Perhaps I wasn't on it long enough for that. Then after the holidays I started noticing the day after I took the pills I felt awful, like I was coming down with the flu. Chills, headache, nausea. I called my doctor and he said to stop taking it. My blood work was always ok during this period.
10 years, many tests, 3 gi doctors, Pentasa 1000mg 3x day
diovan, amlodipine, simvastatin,levothyroxine, sertraline, lyrica, failed methotrexate, failing azathioprine