Lialda - anyone experience heart related problems?

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D-3 of 5
New Member

Date Joined Feb 2009
Total Posts : 4
   Posted 3/1/2009 8:53 PM (GMT -7)   
I started Lialda 3x daily on 2/13/2009 and have noticed some increase in heart rate and blood pressure in addition to an increase of my blood pressure machine saying irregular heart rate. 
Has anyone else experienced similar issues on Lialda?  Feel free to post any other experience with Lialda, good or bad.
Please keep in mind that I occasionally have irregular heartrate but not with the same frequency as recently or with the same increase in heart rate.  I have copied and pasted my most recent blood pressure log and it is obvious that soon after starting Lialda my blood pressure went up.  This could be coincidence since I start Lialda due to a new flare up of the colitis which often increases my blood pressure and heart rate a bit just from the inflammation.  The Lialda did seem to help after the first week as the bleeding had stopped and the mucus discharge following bowel movements was much less.
Date Time BP H-Rate Notes
2-Mar 12:00am 140/93 98  
1-Mar 11:14pm 148/95 101 irregular heartrate
1-Mar 5:33pm 148/101 93  
1-Mar 1:16pm 142/93 84  
1-Mar 1:07 140/93 77 irregular heartrate, stopped Lialda
28-Feb 12:44pm 146/97 73 irregular heartrate
26-Feb 10:11pm 135/98 98  
24-Feb 9:48pm 106/58 116 irregular heartrate
23-Feb 11:48pm 135/98 95  
21-Feb 7:12am 135/90 98  
21-Feb 1:05am 160/101 118 night sweats wake up
19-Feb 10:16pm 127/83 72  
16-Feb 9:42pm 119/85 80  
13-Feb 7:15am 126/85 65 (Started Lialda 3X daily)
12-Feb 7:10am 130/84 77  
11-Feb 10:18pm 125/78 79  
10-Feb 11:35pm 118/80 68  
9-Feb 7:19am 130/84 73  

New Member

Date Joined Nov 2007
Total Posts : 13
   Posted 3/2/2009 12:41 AM (GMT -7)   
I've been on Lialda (3x daily) since switching from Pentasa around October and haven't experienced any problems. I don't regularly check my heart rate or blood pressure, but everything was apparently normal when they checked it at my last doctor appointment in early January. Since you mention it, though, I do vaguely recall reading that increased heart rate was a rare side effect.

New Member

Date Joined Jul 2008
Total Posts : 13
   Posted 3/2/2009 5:04 AM (GMT -7)   
I don't have any issues with Lialda ... but I take 3.6g/day all at once.

D-3 of 5
New Member

Date Joined Feb 2009
Total Posts : 4
   Posted 3/7/2009 4:22 AM (GMT -7)   
I am back home now.
3/2/2009 in the afternoon I went to see my Doctor and while walking in I noticed a slight difficulty in catching my breath.
I went to my Family Doctor and he did an EKG which showed some changes which could have been a problem so off to the ER I went and arrived at 5pm.
While in the ER they performed 3 EKGs and did several blood tests. The first test showed ever so slightly elevated cardiac enzymes.

Somewhere close to 8pm the heart made a sudden change in the EKG and the cardiac enzymes indicated a heart attack.

They rushed to pump me full of the medications and I was being transferred to another hospital Cardiac Cath Lab that was waiting for me.

No heart vessel blockages found at all during the cardiac cath procedure and I had the best Cardiologist in the area performing it so he double checked everything.
A follow up Echo Cardiogram the next morning showed hypo-kinesis (low movement) in a portion of the heart.

The final diagnosis was a stress related cardiomyopathy. The long term stress on the heart from the Lialda inflammation, plus the stress at work, and the stress of the colitis flare up, all combined to trigger the heart attack.

Had I not been in the ER at just the right moment and already had the preventative medications in my body, it would have gone into full cardiac arrest and I most likely would have had major damage at that point with the heart going into fibrillation.

My advice to anyone with any form of Colitis or other long term Chronic illness which can significantly impact your life, please keep a log of your heart rate and blood pressure, if you start having changes in your heart rate and blood pressure that lasts more than a day, please see your Doctor earlier rather than later.
I want to add one last note, because I was seeking treatment before full cardiac arrest, I am looking at very little to no permanent damage to the heart muscle and will likely have 100% recovery of heart function in a couple of months.  The early treatment in my case saved me from a much more serious outcome.
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