I failed Humira

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Regular Member

Date Joined Jan 2006
Total Posts : 303
   Posted 3/5/2009 8:29 PM (GMT -7)   
Humira is no good for me . I have not tried anything else exept for pred. Based on research I thinking of trying  either Rifaximin or Cimzia or remicade.
Anyone have suggestions.
30yo male
Currently on LDN for Crohn's with good results
63cm resection in '08, exausted all meds except pred :)
Avascular necrosis of both hips, Degenerative Disk disease with 5 herniated disk, Asthma, etc etc....

Regular Member

Date Joined Apr 2007
Total Posts : 165
   Posted 3/5/2009 8:33 PM (GMT -7)   
Its okay buddy....   Humira was not any good for me, neither....
28 Yrs
Newly diagnosed with Crohns

Veteran Member

Date Joined Apr 2008
Total Posts : 1753
   Posted 3/5/2009 8:40 PM (GMT -7)   
Is there no maintenance medication you can take like pentasa or asacol? Sometimes certain medications just aren't enough by themselves...
20 years old, Diagnosed with moderate to severe Crohn's and Colitis in May of 2008.
Currently taking:
Prednisone 5 mg, pentasa 2 pills 4x a day, bentyl as needed, omeprazole in the morning, prenatal multivitamin, humira every other week, and good probiotics.
Surgery for ectopic pregnancy most likely the result of severe Crohn's inflammation in July of 2008.
Attempting a diet without refined sugars, high fat content, bleached or bromated flour, most dairy, red meat, and avoiding anything spicy like the plague. Also refuse to eat anything with trans fat or high fructose/corn syrup.
"He who has a why to live for can bear with almost any how."

Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 3/5/2009 8:42 PM (GMT -7)   
I'm really sorry to hear that. I don't know, if Humira doesn't work for me I think I'm going for surgery. I see you just had surgery last year so I guess you don't want to do that already. I think some people here had some good results on Cimzia after failing Humira. Crohn's Daddy seemed to be doing well, but he hasn't updated his post in ages, which is probably a good sign.

Good luck and keep us posted.
32 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira. 25mg prednisone. Udo's Choice Probiotics (30 billion).

Tried SCD, didn't work, now avoiding gluten and dairy.

Veteran Member

Date Joined Aug 2007
Total Posts : 1202
   Posted 3/5/2009 9:20 PM (GMT -7)   
Remicade had me in remission for two years before I lost the response. Then I failed Humira. Now trying Cimzia, but only at week 3 so it's hard to tell. I also re-started Xifaxan tonight. (That's the brand name for rifaximin.) I took it previously for a couple of months and it seemed to help. Why not start both?

It's hard to fail a drug, I totally am with you on that one. Just remember there are new options all the time. And, as much as we hate them, steroids can help us through a tough spot. Hang in there!
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine  --rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08 => STOPPED 10/3/08 - now 2 months into it & it was the right decision
--currently taking budesonide suppositories, 3mg at night.  SLIPPING big time.  Started Cimzia first dose 2/10/09.  Dx Osteoporosis 10/08 started Forteo 1/27/09
--single mom to 11-yr-old girl

Regular Member

Date Joined Oct 2007
Total Posts : 33
   Posted 3/6/2009 6:43 AM (GMT -7)   
Wait, wait.... I've heard that if you stop taking remicade you can build an immunity to it, but you stopped getting a response WHILE taking it?! o.O

My GI and Rheumatologist want me on remicade because I failed Pentasa, lialda, and a billion other ones. i was kinda becoming okay with it until that last post....

now i'm worried. Can't we get an immune system transplant?
Diagnosed CD in Dec 06', re-sectional Dec '07 and another April '08 (12" all together)
Currently on: Pentasa, Yasmin (9 week intervals), occasional Iron supplements.

Veteran Member

Date Joined Aug 2007
Total Posts : 884
   Posted 3/6/2009 11:19 AM (GMT -7)   

Spifficial, yes, you can lose response to Remicade while taking it.  I had good results on it for a year or so, then started losing response.  We increased the frequency of the doses, which maybe helped for a while, and then I started losing response again.  Then, I started having allergic reactions to it and had to stop anyway.  I'm opposite of most people in that I took Cimzia before Humira (by being in a clinical trial for Cimzia).  When the trial ended, we decided to try Humira instead to see if it helped more with the arthritis, but I don't know that Humira works any better than the Cimzia in that regard.  Both Cimzia and Humira have kept my Crohn's in remission. 


Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 

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