Is this the only change you have made? No other change in medication or diet at all? Can you get/borrow something to check your blood pressure at home while sitting and then just after standing to see if it is a blood pressure issue? I had issues that I thought were blood pressure related (not from pentasa) and I borrowed a blood pressure cuff to keep track of my pressure for a few days to monitor it. But with toes involved now, I might be thinking about calling the doctor, or stopping the pentasa for a few days to see what happens. I have found that doctors are not as helpful on side effects as good old fashioned detective work. Most of the time when I think I am having a reaction to a medication, if I ask my doctor, I get a "gee, I don't think that could be the reason". But if I do the elimination on my own, then I usually have my answer. OR, check with the pharmacist, they seem to have much more info than doctors on what side effects could be too.
I hope you figure it out and the headaches don't get much worse.
CD 20 years officially, 30 unofficially. 3 resections '93, '95 '97
Managing with strict low residue diet, keeping symptoms to a minimum. All test show small amount of ulceration, still have occasional blockages. But still have a great time with my 2 daughters and husband!
Prednisone, 6MP,Prevacid, B12 shots, Bentyl, Xifaxan.....