Remicade and Imuran together?

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Regular Member

Date Joined Nov 2007
Total Posts : 497
   Posted 3/12/2009 2:06 PM (GMT -7)   
I was on Imuran but flared and my GI had me start Remicade.  I was still on the Imuran for my first 3 infusions and felt GREAT.  After that, my GI took me off Imuran and I had my 4th infusion last week.  Anyhow, I am going into a flare.  Looking back, I really think the Imuran with the Remicade was what was helping me.  I called and left a message for my GI to see if I can get back on the Imuran.  I tried MTX a while back, and unfortunately it didn't work for me.
If anyone here has/is on both together, please let me know what your opinion is and if it has helped you. 
Thanks so much!

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Date Joined Nov 2003
Total Posts : 7119
   Posted 3/12/2009 4:39 PM (GMT -7)   
I took both Imuran and Remicade together. In fact I started Imuran 4 days before my first infusion. Of course, at that time it was considered beneficial to be on both at the same time because there was evidence that it reduced the chance of infusion reactions. Now there is some concern about people being on both at the same time because of a greater risk of developing ?? I am drawing a blank as to the issue - and can't find it now - my darn lupus brain fog.

I was on Remicade for 2.5 years. I have been taking Imuran for 4.5 years. Remicade put my Crohn's into remission and I believe that Imuran has kept it that way. I saw my GI today and he said he has others that have maintained remission on Imuran for quite a long time.

I will be interested in what your GI says. I hope you can get things resolved quickly.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 3/12/2009 4:45 PM (GMT -7)   
Ides - is lymphoma what you're trying to remember?
Co-Moderator Crohn's Forum.

Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 3/12/2009 5:30 PM (GMT -7)   
Ya I think it's cancer, Ides. If this Humira gets me into remission I might consider switching back over to 6MP and stopping the Humira before I develop anti-bodies to it.

Of course if the 6MP doesn't hold me in remission I might not be able to go back to Humira so I guess it would be a bit of a gamble.
32 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira. 22.5mg prednisone. Udo's Choice Probiotics (30 billion).

Tried SCD, didn't work, now avoiding gluten and dairy.

Veteran Member

Date Joined Apr 2005
Total Posts : 2346
   Posted 3/12/2009 6:08 PM (GMT -7)   
I was on both together for 3 yrs. I stopped the imuran because of elevated liver levels. I have continued the remicade. They don't recommend it together anymore.

Veteran Member

Date Joined Mar 2007
Total Posts : 1632
   Posted 3/12/2009 6:26 PM (GMT -7)   
The concern about imuran together with Remicade is for a specific type of lymphoma, a rare but just-about-incurable form known as hepatosplenic t-cell lymphoma.  It's only been reported a few times, and mostly in young adults/teens, but it's almost always fatal.
The second concern of taking imuran together with Remicade is that the combined immunosuppression greatly increases the chances of contracting an opportunistic infection, compared with just taking one or the other.
Taking imuran, Remicade, and prednisone increases the chances even higher -- much higher, in fact.

Regular Member

Date Joined Mar 2005
Total Posts : 357
   Posted 3/13/2009 5:00 AM (GMT -7)   
I currently take 6MP and am going to be starting Remicade in a few weeks. My doctor told me that taking the two together causes a <1% chance of lymphoma, so they prefer not to have a person on both at the same time. She also told me that I'll probably stay on the 6MP for up to a year until the Remicade can fully "kick in".
32 year old female... diagnosed with Crohn's/Colitis at age 16, then with Proctitis in 2005... right hemi-coloctomy April 2001 (removed 12 inches)... currently taking 100mg 6MP, Canasa, acidolpholus, Protonix, B12 injections once a month, tapering dose of 40mg Prednisone, Bentil and Percoset as needed... considering Remicade

Regular Member

Date Joined Apr 2004
Total Posts : 94
   Posted 3/13/2009 10:42 AM (GMT -7)   
I've been on Imuran for over 2.5 years now and I've been put on Humira 2.5 weeks ago. My doctor told me she would keep me on Imuran for 6 more months because Imuran slows down the making of anti-bodies to Humira. She said 6 months is tops because both meds can cause lymphoma and when taken together the risk is even greater and definitely not something to joke around with.

So yes, both you and your doc are right. You do feel worse without Imuran and being on Imuran and Remicade did help you but at the same time 6 months is really really it. That's the way they do it in Europe. I'd probably ask my doctor about this and tell him that we should try it for at least 6 months. If you haven't already developed too many anti-bodies. My doc also decreased my Imuran dose to 75mg and I'm guessing we will be decreasing it during this 6 month period before fully stopping.

I know I am scared as heck about stopping Imuran even though I know it's necessary. I've talked to some people I ran into at my hospital and they all had the same problem - quitting Imuran after being on Remicade/Humira for 6 months just led them into relaps once again.

I'm really sorry this happened to you :( Good luck!
21 yr. old with crohn colitis. Diagnosed in March 2004. No surgeries so far.

Regular Member

Date Joined Aug 2003
Total Posts : 303
   Posted 3/15/2009 1:01 PM (GMT -7)   
Same thing happened to me - I was on both Imuran and Remicade and then Imuran and Humira. I stopped the Imuran while continuing Humira and started flaring, so I went back on Imuran. Then I got pregnant and was able to stop taking Imuran and haven't been on it or needed it since.

Good luck!
Dx in early 1999
Resection in June 2006
Currently on Humira

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