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Regular Member

Date Joined Jan 2009
Total Posts : 394
   Posted 4/3/2009 9:45 AM (GMT -7)   
My daughter has been in a flare for 3 weeks now. Cortifoam is not working and her Dr has mentioned Methotrexate.  Has anyone here had experience with this drug?  She took 6MP for 2 weeks and developed severe joint pain and had to stop taking it.  She is currently on 2400 mg of Asacol.  Any info would be appreciated.
10 yr old daughter diagnosed with "UC-like Crohn's" 12/08
currently on 2400 mg Asacol 

Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 4/3/2009 9:50 AM (GMT -7)   
Didn't do much for me (25mg injections), but some have done well on it. Need blood tests to check liver and folic acid supplementation.
32 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. 17.5mg prednisone. Udo's Choice Probiotics (30 billion). Can't tolerate any iron supplements.

Tried SCD, didn't work, now avoiding gluten and dairy.

Regular Member

Date Joined Apr 2008
Total Posts : 289
   Posted 4/3/2009 11:22 AM (GMT -7)   

MTX for about 6mo. 

I was first started with 6wks of injection 1/x week and I had FABULOUS results!  I loved it!  It was like I had my life back!  Then I was switched to oral pills 1/x week and side effects of nausea started in and they did not appear to be as effective as the injections had been.  I asked my Dr if I could resume injections, but I wanted to give them to myself.  Darn chemo-Dr office who was administering my shots those first six weeks wanted a $30 co-pay every week!...and lets not forget what they billed to my insurance for those office visits that took all of 2min to jab me! 

No, thanks.  I'd rather jab myself and save $120/month, thankyouverymuch.

Doing well, though I have not regained that first bit of great success I had before I started the pills.


I have the ability of single-minded determination and accurate project focu....Hey, look, a cat!
Crohn's and UC are pretty darn crappy, but if you can't laugh at yourself, you'll cry......I'd much rather laugh.
2001 Dx'd with UC.  No remission.  No improvement with Remicade.  5/2008 surgery, removal of 6" of left side colon.  Dx changed to Crohn's.  Remission for 8-9wks after surgery, symptoms returned after resuming 6MP.  Changed maintenance med to Methotrexate (MTX) and had great results with IM injections.  Nausea and symptoms returning with oral MTX.  Switched back to IM injections and am slowly improving.

Regular Member

Date Joined Mar 2008
Total Posts : 382
   Posted 4/3/2009 11:45 AM (GMT -7)   
Started with 25mg. MTX injections last September and reduced to 15mg. in January. No side effects and colonoscopy in January showed improvement. I have a stricture which subsequent internal ultrasound showed deep scar tissue so am having surgery.
And yes you need regular bloodwork and folic acid.
55 yr. old F dx. CD 07/07
Was on prednisone for three months but no medication for next 11 months.
Started weekly methotrexate injections 09/22/08.
Sigmoidectomy scheduled for May 11/2009

Regular Member

Date Joined May 2006
Total Posts : 229
   Posted 4/3/2009 4:08 PM (GMT -7)   
I take methotrexate injections as well (15mg per week). Seems to be kinda tough to remember to take them sometimes. And yes, I do take folic acid supplements, maybe 1-2mg per day. It's supposed to be good for reducing some side effects like further stomach upset or hairloss. And yes, there are the montly blood tests. As for effectiveness, I can't say exactly how effective it is since i started remicade at the same time. But I feel that it does help cause i got a cold for awhile and i wasn't due for my remicade for awhile but i stopped taking the shots for like 3 weeks and I think I felt worse afterwards. So I think they do help fairly well, but it's not quite a miracle worker for me. If your just taking Asacol right now though, which isn't considered too strong, you might find methotrexate fairly effective for you. Taking methotrexate orally is supposed to cause more stomach upset, and I inject the shots myself. Theres nothing to it really, just get a nurse or doctor to show you how. It'll save you time and money in the long run.
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