Choosing the least painful humira injection site...

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New Member

Date Joined Apr 2009
Total Posts : 1
   Posted 4/20/2009 8:38 AM (GMT -7)   
Hi, new to this board. 38 y/ o female with Crohn's with one resection. Doing well, on Humira, have only been giving pen shots in stomach, but wondering if the top of the leg hurts more or less. my legs are not as "fat" as my stomach! When people say thigh, they are talking "lap" right? thats what the instructions show.

Regular Member

Date Joined Oct 2004
Total Posts : 35
   Posted 4/20/2009 9:14 AM (GMT -7)   
I had been only doing shots in the stomach until last month. Had to have a colostomy and still have drain tube in stomach. So yesterday when I started back on my shots I did one in my upper thigh. I pinched up an area that I had pre-iced. It stung like crazy for the 10 seconds it was going in but I left ice on for a while and I can't even tell I had a shot now. My thigh didn't hurt at all last night. I did it about 6 inches or so out from where my leg starts.

Regular Member

Date Joined Apr 2008
Total Posts : 60
   Posted 4/20/2009 9:59 AM (GMT -7)   

I always inject in my upper thigh, it only hurts for about 5-10 seconds then its done.

I almost tried in my stomach, but I got scared, thought it would hurt worse, so I just alternate thighs...

good luck, Kelly

Regular Member

Date Joined Aug 2003
Total Posts : 303
   Posted 4/20/2009 10:51 AM (GMT -7)   
For me, injecting it in my thigh hurts WAY worse than in my stomach.
Dx in early 1999
Resection in June 2006
Currently on Humira

Regular Member

Date Joined Mar 2009
Total Posts : 318
   Posted 4/20/2009 12:38 PM (GMT -7)   
Hi all i've been on Humira now for 3 months going on 4 and have always injected in the top of my legs switching each one each week and it does sting for the 10 seconds but thats it then it goes away i don't use ice but i do get alot of itching and swelling after wards i can't inject my belly cause there is to much scare tissue,i also use the pen its so much easier than the methotraxate having to fill the needle and i could never see if i had enough or to much but i would only inject where i was taught to did you have a nurse in or a VON for your traning. Jenn

Post Edited By Moderator (Nanners) : 4/18/2011 12:38:21 PM (GMT-6)

Veteran Member

Date Joined Feb 2003
Total Posts : 1811
   Posted 4/20/2009 12:41 PM (GMT -7)   
I have never tried the belly. Too chicken. I did the initial 4 shots in the thigh and I will never do it again. My husband gives me the shot in the fatty part of the back of my arm (GI said this is FINE). I don't think it hurts any less, but at least I don't have to see it and I don't have to stick myself.

Regular Member

Date Joined Feb 2009
Total Posts : 139
   Posted 4/20/2009 1:06 PM (GMT -7)   
I've been on humira for a month now...due tonight as a matter of fact...I have only done the shots on my thigh and I have no problems with sting for a few seconds and thats it...after a couple of hours I can't even tell where I did the shot...I don't ice either....
42 year old woman diagnosed with UC 1991, Jpouch surgery 1992, Crohn's diagnosis 2009
Current meds: 800mg xifaxin, 6mg entocort, Humira (started 3/23/09), synthroid, aciphex

Regular Member

Date Joined Sep 2005
Total Posts : 83
   Posted 4/20/2009 2:05 PM (GMT -7)   

I have been on Humira for about a year and a half.  For the first 8-10 months I gave shots (pen) in the thighs, but decided to try the stomach.  Have been giving them there since.  For me it is less painful in the stomach, plus it gave my thighs a rest!! :-)


Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 4/20/2009 2:33 PM (GMT -7)   
I do my shots in the thigh (lap), but I don't notice much difference between there and my stomach. Just a little sting and then it's over, which surprises me because I don't have an ounce of fat on me.
32 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. 15mg prednisone. Udo's Choice Probiotics (30 billion). Can't tolerate any iron supplements or infusions.

Tried SCD, didn't work, now avoiding gluten and dairy.

Go Saskatchewan Roughriders!

Veteran Member

Date Joined Apr 2008
Total Posts : 1753
   Posted 4/20/2009 5:24 PM (GMT -7)   
I've been on humira since September of last year, and I have always injected in the the thighs. It hurt pretty badly at first, but I gradually became accustomed to it so that the only part I dislike about it now is steeling myself before the shot goes in. I can't do it on my stomach...
20 years old, Diagnosed with moderate to severe Crohn's and Colitis in May of 2008.
Currently taking:
Prednisone 10 mg, pentasa 2 pills 4x a day, bentyl as needed, omeprazole in the morning, prenatal multivitamin, humira every other week, and Align probiotics given to me by my GI.
Surgery for ectopic pregnancy most likely the result of severe Crohn's inflammation in July of 2008.
Diet almost completely without refined sugars, wheat, flour, gluten, high lactose dairy, and/or junk food in general.
Learning how to live again.
"He who has a why to live for can bear with almost any how."

Veteran Member

Date Joined May 2007
Total Posts : 1488
   Posted 4/20/2009 7:23 PM (GMT -7)   
I ice before my shots too and I can tell you that ice pack feels wayyyy better on the thigh than the stomach for me! I've done both sites and prefer the thigh best.
Dx'd Jan'06, 1st Resection 7/06, Humira, Imuran, B12 injections, Nexium, Lexapro, Nulev, Glucosamine, Multi-Vitamin, Calcium Citrate, Ultracet. Secondary conditions: Psorasis, Osteoarthritis, Fibromyalgia, Lactose Intolerant, gallstones, kidney stones & peri-menopausal.

Regular Member

Date Joined Jan 2009
Total Posts : 29
   Posted 4/21/2009 11:33 AM (GMT -7)   
I do the inside of my thighs, there's more fat there. My doc said that anywhere into fat is basically fine. The instructions suggest your thigh and belly so you can see the "meter" as it goes in. I need my boyfriend's help with mine, so he can stick me wherever he likes... (It's a good running joke between us, sorry for being crude.) :)
Diagnosed with Crohn’s Disease in Jan 2007, though sick since mid 90’s. Currently on Humira and Protonix. Have had success with Entocort and Cipro; negative experience with Methotrexate.

Regular Member

Date Joined Apr 2007
Total Posts : 41
   Posted 4/21/2009 12:24 PM (GMT -7)   
For me the stomach hurts far less than the leg. Sometimes I wonder if the
pins are filled different. Some I don't feel at all and some hurt bad.
Crohns dx in 2002. ilieum and colon resection 2002. Ilieum resection 2007.
Started Humira dec, 08

Regular Member

Date Joined Jan 2008
Total Posts : 28
   Posted 4/21/2009 1:43 PM (GMT -7)   
I alternate every shot. I do not use ice. Ice numbs you to the coldness it doesnt numb you to the needle imo.  But I do think that the belly is better to use than the thighs. Neither place really hurts  but I do prefer the belly.

Veteran Member

Date Joined Dec 2005
Total Posts : 1768
   Posted 4/21/2009 1:55 PM (GMT -7)   
For me, the shots hurt far more in the thigh. Maybe because I have less fat on my legs than stomach? Either way, I'll never stick myself in the leg again!

31 yr old female-dx with Crohn's in '97 after emergency resection and appendectomy, 2nd resection '05
Currently on Humira, Prilosec, Effexor, Seroquel, Calcium, Vit D, sublingual B12; phenergan, ultram, clonazepam as needed

Regular Member

Date Joined Mar 2009
Total Posts : 52
   Posted 4/21/2009 3:51 PM (GMT -7)   
I prefer the back of my arm (via husbands help). The nurse said I could also get the shot on my butt. If I have to give the shot to myself, I choose the stomach. I do not use ice.

New Member

Date Joined Apr 2011
Total Posts : 4
   Posted 4/17/2011 8:02 PM (GMT -7)   
Has anyone else been told by their Dr. that they could inject Humira into the Buttocks?  I'm getting too saturated with needle sticks in two recommended places.

Regular Member

Date Joined Mar 2003
Total Posts : 73
   Posted 4/17/2011 8:23 PM (GMT -7)   
I tried the upper leg once and will never again, hurt like heck and left a bruise. I use the stomach and still hurts but not as bad as the leg.

New Member

Date Joined Apr 2011
Total Posts : 4
   Posted 4/17/2011 8:53 PM (GMT -7)   
Yes, I had the same bruising and pain when I tried the upper thigh. Still thinking about trying the butt cheek!

Regular Member

Date Joined Oct 2009
Total Posts : 48
   Posted 4/18/2011 12:26 AM (GMT -7)   
ive been doing mine in the legs, hurts but only for 5 seconds or so. How long has it taken everyone here for the humira to really work well. ive been on it since January, noticing some improvement, but still get days of pain. I just started altering my diet to see if that helps too.

Regular Member

Date Joined Jul 2009
Total Posts : 61
   Posted 4/18/2011 7:14 AM (GMT -7)   
I started out on the top of my thigh and it would bruise and hurt. After getting GI approval, I started injecting on the inner and outer thigh (the fatest parts). This seems to hurt the least. I often get toward my hip area. Try different areas and find one that works for you.
Diagnosed with Crohns in 1998. Been on and off pred, entocort, immuran, asacol. Remicade every 6 weeks along with Asacol worked great for 1 yr. Began having joint pain 01/2010. Switched to Humira May 2010 and asacol. Joint paion finally under control in July!! Pregnant due in November.

New Member

Date Joined Mar 2011
Total Posts : 13
   Posted 4/18/2011 10:44 AM (GMT -7)   
Too scared to try the stomach, for some reason I feel that it would hurt more in that area. I take two shot per week, one each in each thigh. I don't ice the area and it doesn't hurt that much. It usually hurt a couple of mins before, but I find it best it I sit in the same spot, the air doesn't hit the injected area while I'm walking.
Hope that helps,

New Member

Date Joined Apr 2011
Total Posts : 4
   Posted 4/18/2011 11:37 AM (GMT -7)   
For justcallmeD-I have ulcerative colitis but have had my colon removed and have an illiostomy.  I take Humira for RA.  It never gave me alot of relief until I went from every 2 weeks to weekly.  That made all the difference in the world.  Still sore in the mornings and take Vicoden and tramadol to get going.  Most people still need some pain meds as well as the Humira but I can definately say it works!  My Rheumatologist says my joints look much improved on x-ray.  My problem now is the constant fatigue!  Still work full time as a Mental Health counselor but sometimes I do not know if I can keep it up.  Don't know what I would do if I worked manuel labor.

Regular Member

Date Joined Aug 2010
Total Posts : 365
   Posted 4/18/2011 1:53 PM (GMT -7)   
I put mine on my stomach and it doesn't hurt that much anymore. I haven't tried my thighs since they don't hurt on my stomach I figure if ain't broke don't fix it. I don't use ice because if anything hurts it's the actual medicine not the needle.
Diagonosed with Crohn's of the Large and Small Intestines Sept 2010
had been suffering for 2 years before
Previously had 3 fistulas and 4 abscesses and had a fistulotomy and drainage
Meds: Started Humira 10/17/2010

New Member

Date Joined Jun 2014
Total Posts : 1
   Posted 6/16/2014 8:32 AM (GMT -7)   
Actually, I got off the pens entirely. It was agony for me, cause the pain increases as the pressure on the site does and the pen... increasing pressure. I got onto the manual syringes and now administer my own (no longer needing S/O assistance. You can administer it as slowly as you need to and it hurts way less. (Pen pain scale starts at 8 and shoots to 12 for me. Syringe starts at 3 and ends at 0 if I manage it right and choose the right site. Some days are better than others) I never minded the needle hit of the pen, but the rest you can keep. There's just something less painful about being in control of it yourself. The key is to slow the injection down so pressure doesn't build up under the skin which is what hurts so much.

The first year the shots would take like 2 minutes or so. now I can get them done in under a minute with 0-1 pain. If it hurts, slow down, pause and let some of the medicine absorb. It does so quickly.

I am interested in alternate sites, though
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