Humira and Methotrexate

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New Member

Date Joined May 2009
Total Posts : 2
   Posted 5/12/2009 3:24 PM (GMT -7)   
I have ankylosing spondylitis and have just been diagnosed with Crohn's disease. My doctor has told me that I need to start Humira and methotrexate. I don't mind the humira because I am on the enbrel but I don't think I want to take the methotrexate.
Do I have to take the methotrexate?

Forum Moderator

Date Joined Nov 2003
Total Posts : 7121
   Posted 5/12/2009 4:02 PM (GMT -7)   
I assume they are STOPPING the Enbrel before starting the Humira. It is contraindicated to take two anti-TNFs at the same time.

Now to your question - it is/was thought that taking an immunosuppressing agent like MTX or Imuran while on an anti-TNF reduced the likelihood of having a reaction to the medication. There reason I said "is/was" is due to a change in thinking after some studies showed that there was an increased risk for lymphoma when taking Remicade and Imuran simultaneously. Physicians of some patients here that were on Remicade and/or Humira and Imuran stopped the Imuran because of this study. Other doctors feel that the risk is quite low and that patients need both. Imuran as is MTX is used as a "maintenance" medication to keep the autoimmune diseases at bay.

I took Remicade and then Humira while on Imuran. I ended up reacting to both TNF agents and just take Imuran now. My CD [guts] are in remission but I am still battling AS problems, primarily enthesitis. about a year ago I was encouraged to switch to MTX but I refused. I enjoy occasionally having drinks with friends or when out for the evening. I was concerned about the effects of alcohol on the liver that was dealing with MTX. Why is it you would prefer not to take it? Recently my rheumy added Plaquenil to my Imuran to battle my autoimmune issues. I do think it is helping.

And I forgot to welcome you to Healing Well - welcome!!
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.

Regular Member

Date Joined Feb 2008
Total Posts : 314
   Posted 5/13/2009 9:52 AM (GMT -7)   
I have responded but accidently posted as a new post instead of reply

Veteran Member

Date Joined Aug 2007
Total Posts : 884
   Posted 5/13/2009 10:05 AM (GMT -7)   
You don't have to take the methotrexate and different drs will give you different answers as to whether or not you should take both together, as Ides said.  One GI at a seminar I went to told me I should take it with Humira.  I asked my GI and he said no, that new studies were saying you shouldn't take them together.  Then, due to an arthritis flare, my rheumy suggested we add methotrexate to the mix and she said that the rheumy world has used them together for years.  My GI ended up saying we could try it if nothing else worked.  I've only been on it for a week so far. 
Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 

New Member

Date Joined May 2009
Total Posts : 2
   Posted 5/13/2009 5:48 PM (GMT -7)   
Thank you for the welcome.
Yes, I would stop enbrel first.
Is imuran the same as methotrexate?
Methotrexate sounds awfully invasive, the liver stuff, no alcohol and possible hair loss, etc. I really just don't want to take it. I don't want to have to worry about what I am doing to my body at 28 yrs old in order to help this other stuff. Also I don't want to have to change my life.
Is it inevitable that without these immunosuppressing agents like MTX and imuran, my body will become immune to humira and the other drugs?
Has anyone heard of any holistic approaches to Crohn's?
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