When Remicade lost effectiveness for me, I tried Humira. It didn't work fast enough, and I HATED giving myself the shots, so I switched to Cimzia.
So far Cimzia is helping. It isn't as obvious as it was with Remicade for me, but I know it's helping. I don't know if any biologic is as helpful with fistulas as Remicade though.
As far as I understand it, Remicade is put into your body with the assistance of a protein or something from a mouse. Eventually, our body figures out how to make an anti-body for the mouse part and that causes the drug to stop working, and in some cases the severe reactions that put us in the ER.
The Cimzia I'm taking is essentially the same medicine as Remicade, but it's DELIVERED in a different system, meaning there is NO mouse part for my body to throw a fit over.
And so far, as I said, it's working.
27f, dx'd CD July '05 after 6 fistula/abscess surgeries
Remicade '05 through '08, with no other maintenance meds
Noticing a real difference with a Gluten-Free diet.
Cimzia (started 2-12-09)
Probiotics, Digestive Enzymes, Forvia vitamins, and calcium chewies
Prednisone free, again! WHOOPIE!