I was prescribed Accutane in the mid 1980s, with warnings about
dry skin, depression, sun damage, potential liver damage, dry eyes/mouth, dizziness.
In the mid 1990s I was diagnosed with Crohn's disease.
I had tried various medications to get myself stabilized with the Crohn's, so I eventually had surgey to remove a good length of small intestine, give me an ileostomy, and sew up my rear.
I don' know cause/effect or correlation, or coincedence, because I have not read any of the scientific literature.