Hi, I was told 2 weeks ago by my GI that he thinks it's time that I move on to Remicade or Imuran. I, too, am VERY RELUCTANT, and quite frankly, terrified of going on the drugs. I have been suffering with swollen joints for three months, and had it continued at the rate it was, I may have broken down and tried one of the drugs. (I've been in remission and on Pentasa for the last four years with hardly any problems. Yay!) My gut is not giving me symptoms, but a colonoscopy confirms the Crohn's is back. I am keeping Remi and Imuran on the back burner as long as I can, but I'm also working to adjust my attitude. (I, too, tend to get the rarest of the rare of many conditions, etc.) I keep thinking that 10 years ago, these drugs weren't around, so I would have almost NO options other than steroids. So while I'm not on these drugs at the moment, I am thankful that they exist. I have had the enzyme/blood test for Imuran and know now that I CAN take it. My GI has written up orders to pretest me for Remi (liver function baseline, etc), but I have yet to get that done. He went ahead and wrote me a prescription for Imuran, which I have not filled. I'm sure he thinks I'm going ahead with the blood tests and having it filled, but I'm not. I don not think he'll give up on me. But I do think he'll respect my decision and will eventually call to see where I am on the decision. I really pray for your peace of mind and guidance to find and do what you think is is YOUR best interest. There is some validity, I think, to not living the rest of your life in miserable and debilitating pain on the very small chance that the drugs could eventually, possibly, down-the-line somewhere have an adverse affect on your health. The risk is real, but it is small. Your life, and all its possiblities are too big not to at least consider these OPTIONS. At least there are some!
Best of luck!