A new study for Crohn's mln0002, anyone heard of it?

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Regular Member

Date Joined Jan 2009
Total Posts : 23
   Posted 6/19/2009 10:06 PM (GMT -7)   
Hello all! I haven't written in quite some time, hope everyone's getting excited that it's summer! So I have been on every med possible and before my doctors and I discussed surgery they suggested I start a new trial study for Crohn's. This study is called mln0002, or the Millennium drug trial. It's a double blind study where you go for an infusion every two weeks etc. The first time was fine and the second infusion knocked the wind out of me...leaving me with the notion that I believe I am getting the drug. I am still recovering from the last infusion but was hoping someone had any information about this drug!!! I know only what was in my gigantic info packet. Thanks so much!
Melissa -- New York City
Diagnosed with Crohn's in 2004

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 6/20/2009 6:52 AM (GMT -7)   
Sorry I haven't heard about it, but hopefully someone will be along soon who has. I am interested in hearing what it is.

Good luck,
Gail *Nanners*
Gail*Nanners* Co-Moderator for Crohns Disease and Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Regular Member

Date Joined Aug 2006
Total Posts : 443
   Posted 6/20/2009 8:08 AM (GMT -7)   
It's new to me so I took a quick look. It is said to act on alpha 4 beta 7 integrin, so I am guessing it is more like Tysabri, which is an alpha 4 integrin inhibitor than Remicade, Humira, or Cimzia, which are TNF-alpha inhibitors. But that's just a guess, because offhand I know nothing about alpha 4 beta 7.

In the one published study I could find (I've only seen the abstract), the remission rate with the higher dose was 37%, which was significantly higher than with a placebo, although not strongly so. The drug is still in development, so they have released very little information.
I'm having trouble with the link to the abstract, but see if this works:

Post Edited (Writer) : 6/20/2009 9:12:46 AM (GMT-6)

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