Does anyone step down from the "big guns" and do ok?

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Regular Member

Date Joined May 2007
Total Posts : 38
   Posted 6/22/2009 10:06 PM (GMT -7)   

I have been on Humira for only 2 weeks now. But so far it has made a huge difference. I put this decision off a long time and now I wish I wouldn't have waited so long. With this said my doctor said this does not have to be a forever thing (which I know from reading everyone's post most people stop taking this within 3 years as it stops working). But he told me that he has patients who they try to step down after so long of being on the big guns-Humira, Remicade etc..

Has any of you experienced this?

DX in 2007. Was on Asacol for almost 2 years and the Entocort for 6 months. That has now stopped working so currently on Prednisone while trying to get up the courage to take Remicade.

Regular Member

Date Joined Dec 2007
Total Posts : 414
   Posted 6/23/2009 2:34 AM (GMT -7)   

Well I suppose that is kind of technically what I do after each flare, I get infliximab/remicade episodically in my case its used as emergency treatment - if I flare I get a dose and then go on my way until symptoms return which for me so far has been anything from 6 months to 3 years.

My GI did try for a while to get me to have it regularly, he said that I could just go on it for a while and then come off it and he has a few patients who have done that but like I said to him I didn't see the point as one dose gets me to where I need to be, having it however many times for the sake of it and to then stop it anyway just seemed pointless to me.

Oh and I'm maintained on methotrexate too, I'd never chance going totally maintenance free and if you were to step down from the big guns immunosuppressives reduce the chance of building up antibodies during the period off so if you need to go back on to them in the future its more likely they'll work for you again as that is probably the main risk off stopping them for a while.


Veteran Member

Date Joined Dec 2008
Total Posts : 947
   Posted 6/23/2009 3:51 PM (GMT -7)   
iI thought that once your on it your on it. I thought that your body built up antibodies to it faster if you stopped using it.
Diagnosed with Crohns in 2001
First and hopefully last Ileocecectomy 2/18/2009

Medications: Asacol, Precription Folic Acid, Multivitamin, 1000mg Calcium, Vitamin D, Probiotics,  Monthly B-12 injections.

Living a Great life with my Wife and my two Chocolate Labs
Hunter & Hailey.
I love them dearly.

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