6mp? Prednisone? Antidepressants? Diets? HELP!

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Regular Member

Date Joined Jan 2009
Total Posts : 23
   Posted 7/21/2009 12:36 PM (GMT -7)   
Good afternoon fellow crohnies! I am writing because I am at a loss...I am so frustrated and overwhelmed right now that I can barely type this out. Bear with me...

I am having a pretty bad flare...recently I was hospitalized and they had me on Prednisone which makes my body go haywire -- so i was weaning off the steroids and once finished, two days later I was back to the way I was before the hospitalization but this time I was bleeding and severe cramping, diarrhea..you know, the works. SO now my doctor wants me on 6mp because it literally is the ONLY medicine I haven't tried and she wants me back to 40 mgs of Prednisone. Plus an antidepressant Lexapro which I told her no too because i am not depressed. i am just frustrated that it's been forever since I have felt even slightly close to normal and i have been on every drug known to man, fda approved and clinical trials!

So I guess my question to the group is has anyone taken 6mp? How does it make you feel and how long does it take to become effective? Should I even consider this? Are there any other options?

Last summer I was actually in remission on a "medicine holiday" as my doc put it. I was on a gluten free diet and doing acupuncture...it worked for a few months then I flared again. Are there any other diets that worked for people?? I really don't want to go back on the Prednisone -- so i am really trying to look for any alternative there is.

if you have tried anything and it's worked please share it! i really hate drugs..i have been on so many that haven't even worked and left me with side effects i can't ever get rid of. =(

Melissa -- New York City
Diagnosed with Crohn's in 2004

Veteran Member

Date Joined Oct 2008
Total Posts : 1343
   Posted 7/21/2009 1:12 PM (GMT -7)   
I've been having success with the Specific Carbohydrate diet. It takes the gluten free diet a step further and to eliminate lactose, sugar, and starch. I wrote an SCD "primer" at the following thread: http://www.healingwell.com/community/default.aspx?f=17&m=1533705

I'm looking in to LDN (Low Dose Naltrexone) as well. While Humira has done good things for me, I think LDN might be better yet. You get it compounded as a cream that you apply once a day. You can read more about it at http://lowdosenaltrexone.org/
34 years old, Crohn's disease for 15 of them
Current Meds: Humira since 7/08, Pentasa, Effexor XR
Supplements: 3 kinds of Fish Oil, Multi-Vitamin, B-Complex, Vitamins D, E, & K, Calcium, Magnesium, Enzymes
SCD since 12/01/08 - eating Stage 3 foods

Veteran Member

Date Joined Mar 2006
Total Posts : 1169
   Posted 7/21/2009 1:32 PM (GMT -7)   
Been on 6mp for several years now and it does very, very well for me, as it does for quite a few people here. Absent side effects (which only seem to bother about 10% of people and are generally relatively minor) it seems to be on of the most widely used and most effective maintenance drugs for CD. It does take 90-120 days to reach full effectiveness, but after that many people do very well with it long term. I would say give it a try!

Regular Member

Date Joined Feb 2009
Total Posts : 128
   Posted 7/21/2009 2:14 PM (GMT -7)   
I have had a lot of success with 6mp and from what I understand it's been around a long time and it's helped a lot of people. If you are going to have really bad side effects from it, you will know very soon and blood work will tell your doctor immediately. So I would think giving it a try is just a step forward in healing your Crohn's. Just my thoughts.
I am a pre-30yr. old who has been diagnosed with Crohn's for 14 years.  Symptoms change from cramping and weight loss to severe anemia with fatigue and diarrhea. 
100mg mecaptopurine, 40mg Prednisone, Darvocet for dessert.  Starting Cimzia this week (fingers crossed).

Regular Member

Date Joined Aug 2006
Total Posts : 443
   Posted 7/21/2009 5:49 PM (GMT -7)   
I also think 6-MP sounds like a good option. It's a great maintenance medication for a lot of people. As others have said, it does take several months to have an effect so you may need something else in the meantime. If you want to avoid prednisone, enteral nutrition (special liquid diet used for several weeks) is a clinically tested option. Doesn't work for everyone, but it can be as effective as steroids, and responders typically see improvement within the first 10 days. You can find more about it by going to the sticky at the top of the threads labeled "Crohn's disease resources" and looking for the link in that thread to "Diet and Nutritional Resources for Crohn's."

Veteran Member

Date Joined Aug 2007
Total Posts : 884
   Posted 7/22/2009 9:39 AM (GMT -7)   
I was on 6mp for about a year and it did nothing but raise my liver enzymes, so we stopped it.  Also, you may not feel depressed at the moment, but the prednisone can do that to you.  I'm already on meds for anxiety but had to have additional meds added when I was on a higher dose of pred (30 mg, I think).  Once we lower the dosage of pred to 10 mg, I didn't feel as anxious/depressed anymore.
Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 7/22/2009 4:25 PM (GMT -7)   
Hi Mel,

Try clicking on the links in my sig: they might give you some ideas of other therapies that you could try, in consultation with your doctors.
Co-Moderator Crohn's Forum.

Medications for Crohn's ~~ Diet and Nutritional Therapy for Crohn's

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