I am aware that the more biologics you're on the less effective they become so is it even worth trying?
Recently published clinical trials have evaluated the response to additional biologics after failure on an initial or second biologic.
The researchers have concluded that there is a good chance you will respond as well to a second or even third biologic as you did to the others. There is less data on use of a third biologic but there is strong data that a second biologic is just as likely to be effective as the first one.
So you may want to discuss this issue with your GI and also get a surgical consult. Surgeons often have a different take on the situation from GI's and they may have a strong opinion about
which way to go that might help you with this decision.
If you have not been on an immune-suppressant (6MP or Methotrexate) it may be worth a trial of that since they affect a different part of the immune system than the biologics. Some people need both, some need one and some the other. Only way to tell is trial and error.
son now 14 1/2, dx CD age 10; current meds: MTX and omeprazole; previous tmts: pred, 6-MP, Humira, entocort, GMCS, exclusive enteral feeds, pentasa, mesalamine enemas, cipro, flagyl, many topical treatments for perianal disease
Post Edited (rlsnights) : 10/27/2010 9:29:34 AM (GMT-6)