Proudmom, I was taking methotrexate along with Humira for the arthritis that I have with my Crohn's. The pills really hurt my stomach, so we switched to injections. They really helped, but raised my liver enzymes pretty high after a couple of months, so they took me off. Now that we've exhausted all other options, we are trying mtx again but on a lower dose. So far, I can't tell that it's helping and I have a feeling it will still raise my liver enzymes. So, that's one thing they will really need to watch. Other than that, I haven't had any side effects.
Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety. Too many meds to list them all. =)