Since you mentioned eosinophils in the biopsy--have his doctors considered that he might have eosinophilic colitis/enteritis? It is a distinct disease, separate from Crohn's/UC. Just mentioning.
Is his Crohn's in the colon only, ileum and colon, etc.? I assume you already did the elemental and elimination diet? And is he still currently using the elemental diet for some or all of his daily calories?
If he has colitis only, the elemental diet may not be effective. It is more effective when there is also disease in the ileum.
Maybe before going to Tysabri you could consider Remicade + MTX or imuran, Humira, cimzia, or other options? If you think the Remicade is working but just not quite doing enough.
By "going holistic," what did your doctor mean? Exclusive elemental, or something else?
Personally I recommend adding probiotics if you have not already. VSL#3 and/or Primadophilus reuteri. Your doctor can prescribe a double-strength version of VSL#3. I use both probiotics above (VSL#3 capsules--not prescriptoin). I also use a liquid diet (Nestle Peptamen or Nutren) daily for ~500 calories and exclusively on bad days or to get into remission. I have found that my inflammation goes down when I am on the cans exclusively and my bloodwork looks great, but the ESR & CRP tend to creep back up as soon as I am getting most of my calories from "real" food.
I also drink a lot of cranberry juice. It is purely speculation...but I was already doing it to prevent UTIs, and research has shown that the nasty bacteria implicated in Crohn's ileitis are similar to the E. coli that cause UTIs.
July 2007 Drug-Induced Liver Injury
January 2008 Crohn's Ileitis
Currently trying... Enteral Nutrition, VSL#3, Primadophilus Reuteri, Folic Acid, Vitamin E