Trouble with PPI's

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

New Member

Date Joined Nov 2006
Total Posts : 15
   Posted 9/6/2009 2:35 PM (GMT -7)   
Hello to my fellow Crohn's sufferers, my name is Ryan.
I was just curious as to how many of you have been on proton pump inhibitors for longer than 1 year and if any of you have had adverse effects from them.
I was on them continuosly for 4 years from 2003-2007. Started out with nexium (horrible D experience), then quickly moved to prevacid which I stayed on for a year until it stopped working for me. I've been on protonix as well which also seemed to become less effective with continued use. Finally, I was on achipex for several months and then something happened and my stomach hasn't been the same since.
The only way I can describe it is I started feeling hungry all the time, even after pretty large meals. At first I couldn't figure out what was going on, I told my doctor who didn't think it was too serious and brushed me off. After experimenting with my medications I discovered that this feeling was mostly relieved by stopping the aciphex. I also lost a few pounds during this time even though I was eating more food.
I've been having to manage my gerd since then with OTC acid blockers and antacids (and these make the hungry uncomfortable  feeling come back if I use them too much). I just couldn't tolerate how those drugs were making me feel. During bad attacks of acid reflux I've tried to go back on other ppi's with the same result, feeling hungry and weight loss. I have told my doctor about it but they don't seem to have any answers and sometimes act like they don't believe me.
I've heard that staying on ppi's long term can be dangerous. I'm just curious if anybody knows anything about what may be going on with me, I had another bad attack of reflux last week and I need some other way to control this besides ppi's.

Veteran Member

Date Joined Jun 2008
Total Posts : 1058
   Posted 9/6/2009 3:17 PM (GMT -7)   
For me, diet control turned out to work well. I took my reflux problem to a naturopath and she had me do some food intolerance testing. After eliminating wheat dairy and a number of others, I no longer had reflux problems.

Turns out PPI's are known to increase the risk of osteoporosis, heart attack, and SIBO (Small Intestinal Bacterial Overgrowth) as well as potentially masking early signs of stomach cancer. There is also some question of whether there is a real benefit in reducing cancer from Barrett's Esophagus.

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 9/6/2009 5:25 PM (GMT -7)   
I have been on PPI's for probably 3-4 years and have not had any bad side effects from them.  Just keeps my GERD in check.
Gail*Nanners* Co-Moderator for Crohns Disease and Anxiety/Panic Forum
Crohn's Disease for over 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium  w/Vit D, and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia, Osteoarthritis, and Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
It's scary when you start making the same noises As your coffee maker.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Veteran Member

Date Joined Oct 2008
Total Posts : 1343
   Posted 9/6/2009 6:23 PM (GMT -7)   
I used to take Protonix, and was on it for about 1 1/2 years (took Ranitidine prior to that). When I started eating SCD, my acid reflux went away and I quit taking it.

I've heard that in some people, acid reflux is actually caused by lack of stomach acid (I know, sounds weird) and taking acid reflux meds just makes it worse. Taking digest enzymes and/or Betaine hcl resolves the problem in these cases.
34 years old, Crohn's disease for 15 of them
Current Meds: Humira since 7/08, Pentasa, Effexor XR
Supplements: 3 kinds of Fish Oil, Multi-Vitamin, B-Complex, Vitamins D, E, & K, Calcium, Magnesium, Enzymes
SCD since 12/01/08 - eating Stage 3 foods

Veteran Member

Date Joined May 2005
Total Posts : 4219
   Posted 9/6/2009 6:27 PM (GMT -7)   
My dad has Barrett's Esophogus and I have bad acid reflux. I have been on PPI's since I was 13 and I am 27 now. I did prilosec for 7 years, twice a day and then it stopped working. I went on prevacid and it never worked. I was then on Nexium twice a day and then when my diarrhea got worse put down to once a day nexium. When that stopped working I got put on a combination of protonix in the morning and zantac at night. It works great for me. I do often feel hungry and feel awful if I don't eat when hungry but I just thought i had some blood sugar issues. I won't be stopping my PPI's anytime soon.
27 Year old married female.  Graduated law school this year and waiting for results of the bar exam.  Start a new job sometime in September.  Diagnosed w/ CD 4 years ago, IBS for over 10 years before that, which was probably the CD. I am sort of lactose intollerant too but can handle anything cultured and do well w/ lactose pills and lactaid. For crohns I am currently on Pentasa 4 pills/4x day and hysociamine prn. I also have bad acid reflux and have been on PPI's since age 13. I have been through prilosec, prevacid, and nexium. Currently I am on Protonix in the morning and Zantac at night.  I take xanax prn for situational anxiety (aka no easy bathroom access). 

Veteran Member

Date Joined May 2003
Total Posts : 9448
   Posted 9/7/2009 5:57 AM (GMT -7)   
Would eating smaller amounts more often ease both the constantly hungry feeling AND reduce the reflux/GERD?? It would seem like a logical thing to try.

Have you tried alternating antibiotics for the first 10 days of each month for several months??? Along w/a good probiotic taken 4 hours before or 2 hours after the antibiotic?? Or is it vice versa? I've forgotten now. Its easiest to use a once a day or at most twice a day antibiotic - and my doctor and I discussed and chose two of the older antibiotics to alternate in the hopes of reducing the risk of antibiotic resistance. We used tetracycline and amoxycillin.
Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.

Regular Member

Date Joined Mar 2008
Total Posts : 176
   Posted 9/7/2009 11:34 AM (GMT -7)   
Hi Ronyan,
I have a weak valve (the valve between the esophagus and stomach), and thus have had GERD my entire life.  I've been on different types of acid reducers since my teens; then progressed to the H2 blockers (Zantac etc.); then progressed to PPIs.  I've probably been on PPIs for at least a decade.
It seems that after I've been on a particular PPI for a long time, after awhile it doesn't seem to work as well.  So then I switch to a different brand of PPI and I again find some relief.  (Currently I'm on Zegerid and it works well for me.) 
I have a fantastic GI doc, and he's not at all concerned about long-term use of PPIs.  He is aware of the osteoporosis link, and suggests regular use of calcium supplements.  He also had me do a Dexa scan in 2007 to check for osteoporosis.  At the time I had the scan, I didn't have osteoporosis, but had some PRE-osteoporosis in one hip.  That doesn't necessarily mean that the PPIs caused it though.  ALL the women in my family had osteoporosis, so it tends to run in my family---and they weren't on PPIs.
Definitely paying attention to what foods cause you reflux, and then avoiding those foods, helps!!  And don't eat 3 hours before bedtime.
Good luck!
54 year old female;
Have had Crohn's of terminal ileum for over 9 yrs.   My first small bowel surgery was on 7-30-09.
On Humira since Dec. 2008.  Allergic/hypersensitivity to Pentasa, Entocort, and 6-MP.  

Regular Member

Date Joined Feb 2009
Total Posts : 82
   Posted 9/7/2009 12:54 PM (GMT -7)   
Hey Ronyan,

That hunger pain sounds like how I would describe my gastritis pain. Unfortunately, Aciphex was what worked for me, but I also had success with Pepcid AC. My PCP once suggested twice daily on the Pepcid instead of once like the package recommends. I would suggest asking your doctor for an upper endoscopy to get checked out for gastritis or maybe even an ulcer.

Good luck.
22 years old, Female.
Diagnosed with Crohn's Ileocolitis November 2008.
Currently taking Humira.

Veteran Member

Date Joined Jun 2008
Total Posts : 1058
   Posted 9/7/2009 1:27 PM (GMT -7)   
Crohn's causes gut permeabitity due to regular inflammation. This permeability allows food allergens to enter the blood stream and cause antibodies to that allergen to form. Thereafter, upon eating that food, the mast cells in the stomach react to the food. One of the products released by the mast cells is histamine. Histamine causes more stomach acid to be released. As well, the mast cells release a host of other inflammatory agents and the stomach is inflamed as well as hyper-acidic. As you know, inflammation can cause gut blockage due to swelling. Similarly, stomach swelling causes the stomach valves to leak. Avoiding food allergies can avoid all this.

On the other hand, taking PPI's reduces acidity. Reduced acidity changes the pH of the stomach enough so that your digestive enzymes don't work. This results in undigested food entering the small intestine. Undigested food slows down peristalsis which allows bacteria to over-grow in the SI (SIBO). Moreover, if your gut is inflamed (as can happen with SIBO), the resulting permeability will allow any food allergens from the undigested food to pass into the bloodstream and create new food allergies, or just inflammation from existing food allergies.

There are several long-term problems associated with PPI's as well. If you go to Google and start typing PPI's into the search, you will see several choices in the auto-complete box to do with heart attacks, osteoporosis and others that are known complications of long-term use of PPI's.

The older H2 blockers target histamine and would be preferable if you cannot manage your problem by diet control.

Link for anyone interested: Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients

Post Edited (Keeper) : 9/7/2009 2:38:47 PM (GMT-6)

New Member

Date Joined Nov 2006
Total Posts : 15
   Posted 9/7/2009 3:37 PM (GMT -7)   
Thanks for all the replies everyone!
Right now the main that is concerning me about the ppi's is that I'm unable to maintain my weight if I try to go on them now. I'm already pretty thin and have been struggling with keeping my weight up since I was disanosed with Crohn's 6 years ago, but it has been even more difficult over the last 2-3 years. My current thinking is that the weight issue is a problem with my small intestine. I'm calling the doc's office tomorrow to let them know how my latest trial with prilosec went last week. (dropped several pounds, increased gas and abdominal discomfort).
Anyways, happy Labor Day!

Regular Member

Date Joined Feb 2006
Total Posts : 422
   Posted 9/7/2009 4:37 PM (GMT -7)   
Hi Ronyan

Hope you get things sorted soon.

I'm on PPI for acid reflux and I can't help but feel it had a lot to do with my current flare-up.

6 x 800mg Asacol daily
1 x 30mg Omeprazol
150mg Levothyroxine daily
HRT for my sins fo being a

Pain meds as and when for back pain...(paracetamol or tramadol)

New Topic Post Reply Printable Version
Forum Information
Currently it is Wednesday, December 13, 2017 2:38 AM (GMT -7)
There are a total of 2,904,692 posts in 318,782 threads.
View Active Threads

Who's Online
This forum has 158164 registered members. Please welcome our newest member, Sickaz.
194 Guest(s), 1 Registered Member(s) are currently online.  Details