It worked great for me for 2 years. I honestly was symptom free.
After 2 years, we started to bump it to 4 weeks instead of 8 or 12. Then, my symptoms kept getting worse... I had my infusion and started to have issues breathing. Nurse slowed it way down, gave me some Benadryl, and we finished it. It almost seemed like it did nothing for me.
about 2 weeks later, I was sicker than a dog and thought I had the flu! This went one for over a week before a colleague made me see her PCP (I didn't have one) who promptly admitted me to the hospital. Evidently I was flaring and didn't recognize the symptoms.
They did a Remicade infusion in the hospital and I reacted to that one - couldn't breathe, blood pressure went way up, face/chest was flushed, etc. The hospital assigned GI said I had built antibodies to the Remicade, evidently, which is why we kept having to bump the dosage, why I was now flaring, and why I was reacting.
So, they pulled me off it. It was a fantastic drug while it lasted. Now that I know my disease better, I can catch myself before I flare that badly again. For instance - I went from Remicade to Humira. Humira has stopped working and I caught it before my flare was out of control. I'm now on Cimzia.