I take it on a Sunday or Monday night just before I go to sleep (sleep off most of the side-effects that way) and take a prochlorperazine tablet on waking to deal with nausea (tried several anti-nausea/sickness meds and this one worked best for me) the nausea should be able to be controlled, if you take it at night and avoid strong smells the next day that helps a lot.
They day I take it will often vary slightly - either 24 hours early or late depending on if I've been out drinking (I'm a uni student and drink like one, doctors are cool with it as my liver function has remained stable despite this for 7 years - they're more concerned that I live my life normally and happily while I can)
I DON'T drink for at least 24 hours before or after my injection, this is just sensible as you don't want your liver to be having too much to process as you will feel like pretty rotten and its not good for it either.
The first couple of doses I took did affect me strongly but this calmed down once my body had got used to the drug (we're talking intense nausea, headaches, visual disturbances - another good reason to take it just before you sleep) but these all subsided once I'd had a few doses. When you first start taking it it might be worth doing on the weekend so it doesn't affect your work or whatever (if you do work or whatever) and you can have a day to chill if you do get side-effects, once you're used to the drug and side-effects are under control you can then consider changing the day if you wish.
Are they putting you on tablets or injections? I've been on both and in my experience the injections give less side-effects - the nauseas definitely lessened so if nauseas an issue for you it might be worth seeing if they'll put you on injections if they aren't already.