6mp and Neutropenia? low white blood cell count

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Regular Member

Date Joined Jul 2004
Total Posts : 114
   Posted 10/28/2009 3:12 PM (GMT -7)   
I stopped 6 mp about a week ago and now am neutropenic with extremely low white blood cells. Anyone else have this experience when they discontinued 6mp?


Regular Member

Date Joined May 2009
Total Posts : 173
   Posted 10/28/2009 3:41 PM (GMT -7)   
I too stopped 6MP a week ago. Gave me diarrhea after about 2 months on it. I toughed it out to 4 months to no avail. My WBC actually went UP the last two blood tests. Kinda weird. Since going off of it I haven't experienced any drop in WBC. My diarrhea, however, dissipated after 2-3 days. I even re-challenged with 6MP after going off a couple weeks ago. D came back, now it's gone again after a week off. I never noticed a benefit from the drug. I start Remicade next week.
"What can't be changed must be endured" - unknown

DX with distal Crohn's colitis Oct 2007, predominantly in rectum
Colozal (750mg): 3 pills 3xdaily
Cortifoam - 1 nightly
6MP - currently at 100mg and waiting for response......

Veteran Member

Date Joined Jul 2006
Total Posts : 6927
   Posted 10/28/2009 3:42 PM (GMT -7)   
I get it when my crohns is heavily bleeding.
Forum Co-moderator - Crohn's Disease/Thyroid Disorders:_All comments have the caveat contact your local health care provider.

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Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 10/28/2009 6:47 PM (GMT -7)   
I've never heard of counts going DOWN after stopping 6MP. What does your GI say? Perhaps your disease activity is picking up now that you're off the 6MP.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.

Go Saskatchewan Roughriders!

Veteran Member

Date Joined Jun 2008
Total Posts : 1058
   Posted 10/29/2009 2:29 PM (GMT -7)   
Normally, 6MP causes neutropenia and stopping it should cause a return to more normal white counts. One possible explanation is lupus or SLE, which causes leukopenia and is helped by 6MP treatment. Stopping the 6MP would cause fewer white cells in that case. Your doctor should be pushed for more testing at the very least.

Veteran Member

Date Joined Jan 2007
Total Posts : 3200
   Posted 10/30/2009 7:51 AM (GMT -7)   
I never had this problem, just pancreatitis. I wish you well.

Too many years with CD
Two bowel resections, several obstructions.
Fibromyalgia and recently diagnosed with chronic pancreatitis and lupus.
B12 Shots bi-weekly

Laughter is the brush that sweeps the cobwebs from our hearts...

Veteran Member

Date Joined Apr 2006
Total Posts : 1885
   Posted 10/30/2009 7:54 AM (GMT -7)   
Is it possible the neutropenia had already developed while you were on 6mp?

Veteran Member

Date Joined Jan 2005
Total Posts : 1823
   Posted 10/30/2009 8:28 AM (GMT -7)   
I had to stop 6mp because of dropping my white count. So I would think that it should come back up after stopping the med.

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