Hey, seems we're kinda in the same boat now. My husband over the past week has developed severe inflammation in his knees and his SI joint in the back, and his neck is really stiff too. He also started running a fever, and his knee was so filled with fluid, he had zero movement in that joint, and was very stiff and sore.
This all started about
3 weeks after his last remicade infusion. He doesn't have any other signs of an infection that can be causing the fever. The GI ordered a ESR, CRP and ANA and Antihistone Antibody test (these last 2 are to check for lupus). We got back the results of the ESR and CRP, and sure enough they are very elevated. In the meantime, I've had to take my husband to the ER to have his knee drained (they got 60cc of fluid out). This morning he went back to the orthopedic guy, and got 80ccs of fluid pulled out, and also injected with hydrocortisone. He is now on 10mgs of prednisone to help with the other joints. He is also on Flexeril (muscle relaxant) and lortab 7.5 mgs for the pain. They also tested the fluid, and said that it was inflammatory in nature, not infectious.
So, now we're left wondering what is going on!! He was fine, and now he can barely hobble with a cane, is running a fever! All within a week. I am thinking that he is having serum sickness, except he doesn't have a rash (serum sickness normally has fever, joint pain/swelling, and a rash), and usually begins between 1-21 days post exposure, which would kinda sorta match up with what's going on with him.
I'm praying he doesn't have drug induced lupus, because that would likely mean that he cannot take anti-tnf agents at all (because they are all the same class drugs). He now has an appt with a rheumy tomorrow afternoon. I guess she'll order more tests, and we'll wait more for answers
Hurry up and wait. I hope we get some answers soon. And I hope you do too.
Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Canasa, Lialda, Remicade, VSL#3, Florastor
In Remission since June 2008
Stopped vancomycin for c-diff Jan 1 2009
C-diff free, until Sep 2, 2009
Fighting c-diff, I guess for life