Wellbutrin for Crohn's - any opinons?

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Regular Member

Date Joined Dec 2005
Total Posts : 47
   Posted 11/11/2009 12:48 PM (GMT -7)   
Has anyone tried taking Wellbutrin for Crohn's? I'd read that it's shown promise so far and is being prescribed off label, so I had my doctor prescribe some. I noticed almost no effect with 150mg but have felt a lot better since he upped it to 300mg. It's relatively cheap, too (I don't have insurance). I've been able to cut my daily immodium dose in half. Just wondering if anyone else has any experiences with this drug because I'm relatively new to it. (Incidentally, I haven't noticed any of the other stuff it's supposed to do - antidepressant, increase libido, encourage weight loss, etc.)

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 11/11/2009 12:57 PM (GMT -7)   
This was a popular subject on the forum a couple of years ago. You might like to do a search.
Co-Moderator Crohn's Forum.

Medications for Crohn's ~~ Diet and Nutritional Therapy for Crohn's ~~ Dealing with Abscesses and Fistulae ~~

Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 11/11/2009 1:49 PM (GMT -7)   
Has it helped any other symptoms, or just the D?
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.

Go Saskatchewan Roughriders!

Veteran Member

Date Joined Jul 2008
Total Posts : 674
   Posted 11/11/2009 5:00 PM (GMT -7)   
I've been on Wellbutrin  for months now, not for Crohns though.  300mg, I haven't noticed any difference with my Crohns.

Dianogsed with Crohns: At 16 years old. 22 years old now.
Surgeries:2 Bowel Resections, Gallbladder Removed, 3 Abscess Cleanings
Current Meds: Cimzia, Methorexate, Vitamin B12 (injections), Nexium.
Next Surgery: Sept 4, 2009 to Take Down Abdominal Fistula!!  (On hold until current flare is under control, boo!)

Veteran Member

Date Joined Mar 2007
Total Posts : 1761
   Posted 11/11/2009 5:34 PM (GMT -7)   
Hi Mag,
Just wondering, what the state is of you abdominal fistula? 
My daughter was diagnosed Feb. 19/07, (13 yrs. old at time of diagnosis), with Crohn's of the Terminal Illium. Has used Prednisone and Pentasa. Started Imuran (02/09), had an abdominal abscess (12/08). 2cm of Stricture.

Regular Member

Date Joined Oct 2006
Total Posts : 405
   Posted 11/12/2009 7:21 AM (GMT -7)   
I just started taking it. Quite frankly my Crohn's is doing it's own thing right now, and I've only taken it two days. My mood is better. I still feel alert and less anxious about things which I guess you could say makes my Crohn's a little better when you think about it.

Veteran Member

Date Joined Feb 2009
Total Posts : 1879
   Posted 11/12/2009 3:53 PM (GMT -7)   
I took it for a few weeks and it made me so constipated. Maybe it is good for people with diarrhea. I am prone to constipation not diarrhea. I really struggle with antidepressants and the effect they have on my colon. On the mayo clinic website, they said they have seen cases of colitis from people who take zoloft and nexium. Kind of makes you wonder what these do to our systems. I am back on cymbalta. At least it doesn't constipate me but I don't like it all that much.
diagnosed 1/09 with "diverticular colitis" ?? location: sigmoid colon
localized scleroderma & IBS, low thyroid,claritin, advair, singulair, lisinopril, progesterone, colazal, fish oil, synthroid, zoloft, wellbutrin, VSL#3 probiotic, Vit. D
Blood test positive for Crohn's via prometheus ibd serology panel

Regular Member

Date Joined Oct 2009
Total Posts : 111
   Posted 11/12/2009 5:58 PM (GMT -7)   
I have taken Wellbutrin XL 300mg for years as an antidepressant. It does not seem to have helped or hindered my intestinal difficulties, but it makes me less crazy. :)
chronic active colitis/possible Crohn's
Lialda 2x/day
darvocet as needed

Carnival Huckster
Regular Member

Date Joined Oct 2009
Total Posts : 159
   Posted 11/12/2009 7:15 PM (GMT -7)   
How does it compare to Prozac? I started taking prozac years ago and swear that it seemed like it was helping ... but then last year while still taking it I became much worse, so perhaps it was just the placebo effect :-)

+ 34 year old male
+ Crohn's Disease DX in 1997, doc said it was "moderate to severe"
+ Currently taking 9mg entocort and 40mg prozac
+ SCD for past 10 years
+ 4,000 mg MSM, Calcium, Vitamin D, Multivitamin, S. boulardii, Acidophilus
+ Section in lower jejunum is badly strictured (5mm wide opening continues for 10cm!) but otherwise no other problems in bowel
+ No surgeries so far

Regular Member

Date Joined Dec 2005
Total Posts : 47
   Posted 11/15/2009 7:16 AM (GMT -7)   
i tried to do a search but all i got were promotional links. maybe i don't know how to search this site very well. :(

and no, i haven't noticed a substantial relief of other symptoms except diarrhea. i still have pain/discomfort, and upper GI symptoms like nausea and heartburn. but hey, if i can function better without being near a bathroom, that's good enough. it hasn't improve my appetite and apparently it's associated with lack of appetite and weight loss and so not given for mental issues to anyone with anorexia or such problems. it has caused pretty frequent headaches, but i think i solved that by taking half a dose twice a day rather than one large time released dose.

that's so interested that people seem to be saying it's helped them a lot with depression and other mental issues. i really don't see much of a difference at all with what it's supposed to do. but good for you guys! :)
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