How long after a remicade infusion can you have a reaction?

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Veteran Member

Date Joined May 2006
Total Posts : 1177
   Posted 11/13/2009 9:06 PM (GMT -7)   
Everything I read says you can have a delayed hypersensitivity reaction to remicade for up to 12 days post infusion (per the remicade brochure). Have reactions happened after that period? Can you post your experiences / what you've heard from others regarding delayed hypersensitivity reaction (due to antibodies to remicade) that have occurred even after 2 weeks post infusion please?

The reason I ask is because the doctors don't think my husband is having a "reaction" to remicade because it was about 23 days after infusion that he started complaining of body pain (SI joint, neck and knee). He also started running a mild fever. Steroids have made him better, but his knee keeps filling up with fluid that needs to be drained a lot. They think that's pretty unheard of for a remicade reaction. He has never had anything like arthritis before . . . so this is completely from out of the blue for us.

So, how improbable is it to have a remicade reaction 23 days post infusion? Is that pretty unheard of?

I just want to make sure I get the doctors to consider all avenues, if there really is a possibility. My husband is now scheduled for his next infusion on Tuesday, and I am so worried that he's going to get worse not better. So anxious in fact, that I can barely keep food down.

So, if you have heard of infusion reactions even 3+ weeks after infusion, please let me know, so that I can talk to his doctors about it.

Thanks for your help.

Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Canasa, Lialda, Remicade, VSL#3, Florastor
In Remission since June 2008
Stopped vancomycin for c-diff Jan 1 2009
C-diff free, until Sep 2, 2009
Fighting c-diff, I guess for life

Veteran Member

Date Joined Jul 2008
Total Posts : 674
   Posted 11/13/2009 10:00 PM (GMT -7)   
I had a reaction about 1 week after my infusion that landed me in the ER.  Mine was full body hives though, nothing like your husbands.  I really don't know, but I do know that when I was on Humira I got such bad joint pains that I refused to take it...maybe it just took a while to get into his sysem for his body to have the reaction.
Dianogsed with Crohns: At 16 years old. 22 years old now.
Surgeries:2 Bowel Resections, Gallbladder Removed, 3 Abscess Cleanings
Current Meds: Cimzia, Methorexate, Vitamin B12 (injections), Nexium.
Next Surgery: Sept 4, 2009 to Take Down Abdominal Fistula!!  (On hold until current flare is under control, boo!)

Veteran Member

Date Joined Jan 2006
Total Posts : 768
   Posted 11/13/2009 11:24 PM (GMT -7)   
I had a reaction that I really understood after the third injection. (Month 3) I had the joint and fever and felt like crap. I had the hives start after the third thing and they biopsied them and learned it was a reaction to the remicade. Humira is in the same category so has some similar characteristics and problems.

Knee swelling is often a mystery in the sports world without being sick. I think whenever the body is breaking down, stuff can happen and there isn't any good explanation for it. But it's there. Keep a watchful eye on it all.

Take care.
This heights by great men reached and kept, were not obtained by sudden flight, but they while their companions slept, were toiling upward in the night.
H.W. Longfellow
Thyroid cancer removed 1988
Stomach problems finally figured out 2001 Crohn's/Colitus
Tried every drug without much success
Colon/rectal cancer removed Aug 2009

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