questions about methotrexate

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Regular Member

Date Joined Aug 2008
Total Posts : 351
   Posted 11/19/2009 3:58 PM (GMT -7)   
Hi everyone.  i'm 27 years old.  i'm married and have one 5 year old child.  i've had crohn's disease for 8 years.  i've done every med out there so far with no success.  never been in remission.  just had a small bowel ressection a year ago with temp ileostomy.  found out that 7 months later the crohn's had reoccured at the reconnection site and was inflammed and had narrowing at the recconection site due to scar tissue and active disease.  iwas put on cimzia.  i've been on it since april of this year.  worked for a while and now has failed.  now doc wants to put me on methotrexate.  i really don't know too much about it.  he told me it's injected once a week.  also he told me CANNOT GET PREGNANT!  my husband wants me to have another baby before i start.  i don';t know what to do.  i need some help.  thanks

Veteran Member

Date Joined Jun 2006
Total Posts : 909
   Posted 11/19/2009 4:40 PM (GMT -7)   
You cannot get pregnant at any point while on MTX. Assuming it works, it is a long-term treatment, so if you really want to have a child in the near future, it is probably not the best drug for you. That said, your health should be your number one concern. You are still young and have plenty of time to have another child. Personally, I would focus on getting yourself healthy again first.

Have you told your GI you are thinking of conceiving? If you really are set on getting pregnant, there are a number of treatments that you can be on while pregnant.
29f, PhD student, originally diagnosed with Crohn's in 2/06
10/09: Prometheus test shows results consistent with UC
10/12/09: beginning treatment for inflammatory arthritis
Currently taking: 7.5mg methotrexate weekly (pills), 2g Pentasa, tapering from 20mg prednisone, 150mg Trazadone, multivitamin, vitamin D, magnesium, probiotics, folic acid

Regular Member

Date Joined Nov 2004
Total Posts : 55
   Posted 11/19/2009 6:04 PM (GMT -7)   
I was on methotrexate for almost a year, when I was stable I got off it and 9 months later got pregnant with my son. I was off it for over two years after he was born but due to humira not being as effective I am back on it again. So it is possible to be on it and then take some time off to have a baby and then go back on it if you need it again. I wish you the best of luck to achieve remission soon so you can concentrate on expanding your family!
Diagnosed Sept. 2004 (two weeks before my wedding)
Currently on 80mg Humira, Prevacid, Methotrexate 25mg and Folic Acid
Have also taken Entocort, Remicade, Pentasa and Imuran

Regular Member

Date Joined Dec 2007
Total Posts : 414
   Posted 11/19/2009 8:11 PM (GMT -7)   
If you go on it you have to be off it for at least 6 months before getting pregnant due to the risks to the foetus. I've had huge success with it though (been on it over 7 years now) I THINK (don't hold me to this!) that Imuran/azathiaprine (very similar drug) you can get pregnant though so that might be worth looking into. Other than that theres meds like remicade/infliximab and humira. Definitely worth having a chat with your GI about your options though, I was put on methotrexate when I was 15 so obviously getting pregnant was not a concern for me at that age but I'm guessing in a few years time I may have to rethink things but at least theres so many more drug options now then back then!

Regular Member

Date Joined Nov 2009
Total Posts : 26
   Posted 11/24/2009 11:32 AM (GMT -7)   
My doctor started me on injectable Methotrexate in March of this year. He said that we were going this route in order to try to get me off of endocort. He also stated that we would start with injectable and then move to the pills.

Has anyone moved from the injectable to the pills? I had mild side effects upon beginning the injections but those have all settled down. My weekly then monthly blood work has all come back fine.

I have been told while on the injectable to avoid any alcohol in the beginning and once the side effects calmed down I could have an occassional drink. I have done this and seemed to have had no problems. Someone has told me that the pills are less harsh on your liver. Not sure if I believe this or not as it did not come from a medical proffessional.

I see my doctor tomorrow to get the results of my last c-scope and am going to talk to him about the switch to the pills and the tapering off of endocort.

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 11/24/2009 1:25 PM (GMT -7)   
I don't have experience with this but I have heard from other members that the nausea was horrible on the pills, but not with the shots.
Gail*Nanners* Co-Moderator for Crohns Disease and Anxiety/Panic Forum
Crohn's Disease for over 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium  w/Vit D, and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia, Osteoarthritis, and Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
It's scary when you start making the same noises As your coffee maker.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*
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