Pentasa Side Effects?

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Regular Member

Date Joined Oct 2009
Total Posts : 253
   Posted 11/24/2009 7:39 PM (GMT -7)   
In the past couple of weeks/months I've had significant back pain, and a very distended stomach/gas pain movement in that area.. I've also been more tired with a headache alot of the time. I haven't really felt quite this bad before with these specific symptoms, which brings me to today. I feel like someone filled me up like a balloon! Anyways I've been reading about pentasa side effects and it says to talk to your doctor if you get gas, back/joint pain, headache, fatigue etc which I have. I have an appointment next Wednesday anyway cause I've felt like crap lately, should I just wait until then? Has anyone else experienced this?
I also feel like I'm losing more hair then usual in the shower!
19 y/o female, diagnosed crohns december 2008
currently taking 500 mg pentasa 4x daily

Regular Member

Date Joined Sep 2008
Total Posts : 211
   Posted 11/24/2009 8:42 PM (GMT -7)   
I didn't feel that way at all on Pentasa. I would ask your gi about your problems...good luck!

37/f   proud single mom of 2

Diagnosed with GERD/Acid Reflex 2002

Diagnosed with IBS 2007

Diagnosed with Arthritis 2007

Diagnosed with UC, then Crohn’s 2007

Diagnosed with Generalized Anxiety Disorder 2008


Starting on REMICADE probably within the next mo.

Current medications: Asacol 2 tablets 3X daily, Imuran 50 mg daily,Endcort 3mg 3X daily, Pentasa 2 500mg caps 2X daily, Prilosec 20 mg 2X daily (if needed), .05 mg Zanax (if needed) Probiotics, Calcuim/Mag/Vit.D. Flinstones multi with Iron and Vit. C 500mg daily

Forum Moderator

Date Joined Nov 2003
Total Posts : 7119
   Posted 11/24/2009 10:50 PM (GMT -7)   
There have been several people here that have reacted badly to the mesalamine drugs like Pentasa and Asacol. I think you should definitely discuss the new symptoms with your doctor. Also, if he/she tries to tell you that it can't possibly be the Pentasa, print out a list of the side effects and show him.
Moderator Crohn's Disease  & Osteoarthritis Forums
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, asthma, severe allergy and a host of other medical problems.

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 11/25/2009 8:18 AM (GMT -7)   
I take Asacol with success, but when I took Pentasa it gave me diarrhea and cramps. Good luck!
Gail*Nanners* Co-Moderator for Crohns Disease and Anxiety/Panic Forum
Crohn's Disease for over 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium  w/Vit D, and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia, Osteoarthritis, and Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
It's scary when you start making the same noises As your coffee maker.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Regular Member

Date Joined Nov 2003
Total Posts : 28
   Posted 11/25/2009 8:26 AM (GMT -7)   
How many pills are you on? I had the same problem when they first put me on Pentasa the doctor I was seing was just a general gastro doctor and i was feeling worse when they put me on pentasa  I ended up trying to find myself a specialized doctor for crohn. When I went to see the new doctor he informed me i was on the wrong dosage which was to low and he also gived me a cipro prescription for 1 month to take at the same time and after that everything was good. I have now been on Pentasa for 10 years and since that day never had any problems.
Maybe its a side effect or maybe you weren't prescribed the right dosage.
Natalie :)

Regular Member

Date Joined Nov 2003
Total Posts : 28
   Posted 11/25/2009 8:33 AM (GMT -7)   
sorry just saw that you had on your signature the amount on pills, i was on 4 x 500mg at first and then they doubled my dosaged to 8 x 500mg (taking 4 when i wake up in the morning and 4 before i go to bed)

Natalie :)
Diagnosed July 2000 with Crohn's been on Pentasa ever since

Veteran Member

Date Joined Mar 2009
Total Posts : 1118
   Posted 11/25/2009 1:40 PM (GMT -7)   
hI I had a similar experience ever since i have been on pentasa i kept getting aches but put it down to being on my feet all day and wearing different shoes but on monday every joint ached it was so painful went to GP he sent me to get a blood test done but said it could be a reaction to the H1N1 shot as that can cause joint pain. I think it may be the pentasa as i had the aches before the shot will speak to my GI in jan. Bevx
Diagnosed with crohn's at 13 now 42
resection, right hemi 1993 In remmision from 93 till last sept with no meds or docs
2 resections small bowel  and fistula jan 09 and given temp stoma.  reversal 1st week of Jan. Meds:Pentasa 500mg 3x day,  B12 shots, every 3 months, iron syrup,loperimide,folic acid,  citalopram 60mg (for Anxiety.)

Regular Member

Date Joined Oct 2009
Total Posts : 253
   Posted 11/25/2009 5:52 PM (GMT -7)   
thanks everyone, I will definitely be printing out my source of pentasa information to ask my GI about it... I'm going through a bit of a rough patch and hoping maybe to be put back on entocort which seemed to work the first time and then maybe a different maintenance med that won't cause excruciating back pain!
19 y/o female, diagnosed crohns december 2008
currently taking 500 mg pentasa 4x daily

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