zpack and crohns flare

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Regular Member

Date Joined Aug 2007
Total Posts : 39
   Posted 12/8/2009 5:04 PM (GMT -7)   
Ok....so I had a sinus infection and unknowingly started a zpack 2 weeks ago only to end up hospitalized with my first crohns flare in 2 1/2 years...now I am out and on Entocort.  This is the last time I am taking oral antibiotics....each flare has come after a course of antiboitic....hmmmmmmm maybe I have found a way to avoid some of this turmoil....anyone else have this kind of connection?

DX AT 39 (2005)

Veteran Member

Date Joined Sep 2006
Total Posts : 2527
   Posted 12/8/2009 5:07 PM (GMT -7)   
I have never had an issue with any antibiotics and have been on the Zpack many times. However this disease has many triggers for different people
Dx with Crohn's 1987, symptoms as early as 1984.
Temp iliostomy February 2007, reversed June 2007, Ovarian cysts, migraines, allergies (incl food allergies) , oral allergy syndrome (diff than true food allergies), Asthma, Gall Bladder removed 1999, Inguenal hernia 1987

Veteran Member

Date Joined Oct 2009
Total Posts : 1070
   Posted 12/8/2009 5:16 PM (GMT -7)   
Might be just the stress on your body from being sick. My most recent flare started right after a hard hike uphill. I was really enjoying the walk and pushed my self and then like the next day I flared. As dragonfly said there seems to be so many different triggers for each of us
I use FD&C Blue dye number 1 and it really seems to help me.  There is SCIENCE behind this.  Just ask me and I will explain it to you.  U/C and Crohn's for 34 years.  Blue dye for one month and I am feeling pretty good!  I am so excited by this but I need others to try it with their doctor's permission.  Simple food coloring!!  BLUE1.  
I can't make money on this, it's already in your kitchen.  I just want to help.
I do 2 drops in 6 ounces of water when I get up, 2 or 3 drops in 16 or 20 ounces of water that I sip all day and then 2 drops in 6 ounces of water at bedtime.   Max of 7 drops a day.  Give it about ten days.  I am NOT a healthcare professional.   Ask your doctor if this is safe for you. 

Veteran Member

Date Joined Apr 2006
Total Posts : 1885
   Posted 12/8/2009 6:19 PM (GMT -7)   
My daughter does fine with Zpack, but a course of Zosyn exacerbated her Crohn's. Also, we think her repeated rounds of Augmentin helped to cause Crohn's.
I've always thought Zpack is one of the safer meds because it is, in fact, one of the meds used to treat Crohn's according to the MAP theory.

Daughter (22) Dx'd Crohn's 3/06. Misdiagnosed for two years, including by top pediatric Crohn's specialist as stress. No symptoms for the past two years. Recent colonoscopy shows stricture gone but still two spots of inflammation in TI. Used LDN to taper off Entocort. Was on Entocort since April 06. Never had D. SCD multivitamin, homemade yogurt, 5000IU vit D3, 500 mg calcium, 27 mg iron, monthly B12 shots, daily oral B12 1000. SCD diet modified to include potatoes and rice. 

Regular Member

Date Joined Oct 2009
Total Posts : 157
   Posted 12/8/2009 6:28 PM (GMT -7)   
I think it depends on the type of Crohn's you have. My new GI just told me that under no normal circumstances should I ever take antibiotics.
I remember before I was diagnosed my GP put me on an antibiotic (pretty sure it was a Zpack) and it was the worst (as I know now) Crohn's pain of my life. After the second pill I absolutely refused to take any more of it because it made me feel so terrible.
Crohn's dx in May 2009, symptoms since October 2008
Currently taking: Pentasa 1 gm/4x daily; Azathioprine 150 mg; Entocort 9mg

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 12/9/2009 8:15 AM (GMT -7)   
Augmentin has been one of the worst antibiotics for my Crohns. I refuse to take it anymore, because it caused such horrible D in me. Hope you get feeling better.
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Veteran Member

Date Joined Oct 2009
Total Posts : 1054
   Posted 12/9/2009 8:58 AM (GMT -7)   
I think my current flare was caused by antibiotics. I had a HORRIBLE sinus infection...the sickest I've ever been, not counting my Crohn's. It lasted 3 weeks, and I was put on Amoxicillin...that made me SO sick (diarrhea 20+ times in a day), so I got on a different antibiotic and finally started feeling better, but then I flared. 6 months later, I'm still tapering off my pred from that.
28 Year old Female
Diagnosed with Crohn's Colitis March 2000
Recent possible diagnosis of IBS-D
Tried Meds: Asacol, Remicade, 6mp, Humira, Xifaxan, Apriso, Rowasa Enemas.
Currently on: 35mg Prednisone, 100mg Imuran, Align, Psyllium Seed Powder, Prenatal Vitamin, Vitamin B 12 Complex, Vitamin D/Calcium, Flomax (for urinary retention). 

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