Serology 7 Test Results

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Veteran Member

Date Joined Nov 2009
Total Posts : 1695
   Posted 12/30/2009 4:17 AM (GMT -7)   
I posted this on the UC forum and didn't get any responses so I thought I'd try this one since this test has been discussed more on this board anyway. Any responses would be greatly appreciated.

I just returned from the GI doctor and am very worried. I can't remember which stat was positive for CD, but one of them came back that way. My C-reactive protein was only 0.15 mg/L though, which is very good.

The doc told me he is pretty much certain it is UC and not CD. The biopsy/pathology results came back and were reported as proctosigmoiditis UC. The inflammation was limited to the innermost layer of the colon. Also, the inflammation was continuous from the rectum up to 25 cm.

I have read that the probability of a positive result for Crohn's being correct is 96%, but I have also read that the test is unreliable. I am so distressed right now and don't know what to think. Could it be both? Why is my C-reactive protein so low if it is CD or both UC and CD?

I am worried to death. I don't want to have to handle another animal so soon after learning about UC. Please let me know your thoughts.

Regular Member

Date Joined Aug 2006
Total Posts : 443
   Posted 12/30/2009 6:30 AM (GMT -7)   
The Serology 7 tests are useful tool in working toward a diagnosis, but are by no means conclusive. Likewise, many patients have high C-reactive protein and ESR during flares of IBD, but in the occasional patient these indicators of inflammation are not particularly useful because the patient can be quite ill without these parameters being much elevated.

When disease activity is restricted to the large intestine, it can be very difficult to tell the difference between ulcerative colitis and Crohn's and there is always the possibility that the diagnosis may one day change. It might be useful to think of yourself as having IBD rather than agonizing too much about which type of IBD it is. Generally speaking, most of the treatments are the same, with the exception of surgery (a curative option for UC but not Crohn's) and enteral nutrition (an effective primary treatment for Crohn's but not for UC). I realize that the uncertainty is frustrating, but remember whichever you have, it's a done deal, you can't change the fact that you have it . Your symptoms are your symptoms, whatever the name the doctor puts on them, so it can help to focus on setting up a plan to deal with the symptoms rather than worrying too much about the specifics of the diagnosis. Just a thought.
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