I have also tried methotrexate. I didnt notice too much change in the 2 months that I was on it. I felt even more fatigued, low energy and low tolerance for any activity. I aslso felt nauseas. I know that some get relief, but we are all so unique, this one med isnt going to work for all of us.
I have also tried Plaquenil for the fatigue and joint pain. This one worked for the first 4 years I used it, but lost its usefulness after this, so I got off of it.
What I am on now is Savella. It doesnt touch any stomach issues, but helps with fatigue and gives me a higher pain tollerance.
best of luck in finding what works for you!