Entocort vs. Cimzia

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Regular Member

Date Joined Feb 2010
Total Posts : 34
   Posted 2/8/2010 4:43 PM (GMT -7)   
I have been taking Entocort for almost four weeks and think I'm starting to experience improvement. I've had a few good days after a terrible 3-4 weeks. During this episode, I had a colonoscopy which showed a severe flare in the colon. The doctor is working on getting me approved for Cimzia. My question is, if the Entocort is working, am I better off just sticking with it and not going the biologic route, or should I go ahead with the Cimzia?  I confused about which one is better for me (if there is such a thing). Often people refer to the biologics as the big guns, so should they be avoided if at all possible?
Just trying to figure it all out. :-)  And I will pose these questions to the doc on Thursday, of course. Thanks!

Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 2/8/2010 9:16 PM (GMT -7)   
Ask him what part of your colon is affected. If it's anything more than the ascending (right side) colon then Entocort will probably not help. Good luck.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.

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Veteran Member

Date Joined Feb 2009
Total Posts : 529
   Posted 2/8/2010 9:19 PM (GMT -7)   
Where in your colon is your disease? As far as I know, Entocort only works in the small intestine and ascending (right) colon. If your flare is severe though, Entocort may not be enough for you. I thought I was getting better too, and now it turns out that I've got a fistula, abscess and I perforated. After a month on Entocort, if you're not feeling almost entirely better, I think you probably need something stronger. It's supposed to clear up a flare in 6 weeks, if it takes any longer than that I'd say it probably isn't strong enough for you (which sounds like the case). I regret not going on something stronger sooner. Doesn't necessarily have to be a biologic, there are a lot of options out there.

Regular Member

Date Joined Feb 2010
Total Posts : 34
   Posted 2/9/2010 4:34 AM (GMT -7)   
Thanks for the feedback. My entire colon is affected but it appears to stop at the TI, which is clear.

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 2/9/2010 7:58 AM (GMT -7)   
Entocort is a steroid that is meant to be used to get the flare under control. The Cimzia will be used to keep your Crohns under control. Have you tried any of the other meds like Imuran or 6mp? Those might be better to start with than going straight to the Cimzia. Good luck!
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Veteran Member

Date Joined Jan 2010
Total Posts : 794
   Posted 2/9/2010 8:40 AM (GMT -7)   

Sorry for hijacking this post but am I understanding this correctly?

Pentasa is a maintenance drug?, Entocort is used to get a flare under control and the immunosuppressants?-is that maintenance/prevention too? Just trying to get it all clear in my mind for Thursdays visit to consultant. Subject to blood test results was going to put son on immunosuppressants Thurs BUT he is now back on solid food (along with Pentasa and 3 weeks of entocort)and so far things are going ok and I would rather that he only takes drugs that are necessary I understand that maintenance drugs are essential but does he really need the suppressants right now? Any thoughts?

OK, think I have just found the anwser after looking up cimzia  which appears to be an immunosuppressant-guess I will have to have this one out with consultant

Post Edited (vixen) : 2/9/2010 8:46:01 AM (GMT-7)

Regular Member

Date Joined Feb 2010
Total Posts : 34
   Posted 2/9/2010 12:13 PM (GMT -7)   

Hi Nanners--

Thank you for the feedback. Is Immuran or 6 MP safer than Cimzia? I'm still unclear on why the Cimzia, Humira and Remicade or considered "big guns." I realize they suppress the immune system and that is scary but don't Immuran and 6 MP have their own scary considerations?

I do appreciate the education. I'm so overwhelmed. :-)

Veteran Member

Date Joined Jul 2006
Total Posts : 6927
   Posted 2/9/2010 4:05 PM (GMT -7)   
A-TNF drugs such as humira and remicade are considered big guns, because they were orginally designed treat advanced sign/symtoms of crohns (such as fistulazing, blood loss, etc.), but more recently the thought has changed to let's get this under control before the disease gets to that advanced state. Because these are generally drugs that take a couple weeks to months to be effective.

Cimzia is the newest drug out of the "big gun" category, but all them are still rather recent.
Immuran and 6mp from my understanding are considered "safer" in part because they have been around longer and we know what their long term effects are. Futhermore there is a slight more risk in taking an injectable or an iv.

Endocourt is also consider by some as a long term treatment drug.

Forum Co-moderator - Crohn's Disease/Thyroid Disorders:_All comments have the caveat contact your local health care provider.

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All that I am and all that I shall ever be, I owe to my Angel Mother.

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