Look at this site for where/how to apply.
one tip when I used them in the past: I put them on my lower back as they pressure from sitting back on my pant waistline kept them in place. Oherwise, placing them on my arms or chest, etc, they always fell off, either from friction or sweat. Watch out not to expose them to heat - showers, hot tubs, etc.
As for pain releif, you should feel it within a day or so ... ask the pharmacist for the half life, etc as I forget. I know that I have a high tolernace to the drug and ended up needing more than one so keep your pain doc in the 'know' how well they are working.
Good luck ... no one needs to be in pain ....
44-single mom diagnosed with Crohn's 2004 via pill camera 6MP kicked into remission (along with modified diet) so went off in 2006.
2009/2010 acute flare and hospitalization - now on Imuran. Currently taking 55 mg prednisone.
Current problem - protruding thrombosed hemorrhoids (external as well as internal).
Fibromyaglia; migraines; herniated disks C5,6 and arthritis in neck; asthma; scolisis in back/arthritis.