My husband has struggled with c-diff. In March 2008, he was admitted to the hospital with a c-diff infection (at this point, we didn't know he also had crohn's). They put him on vancomycin, and he still didn't get better. Finally they did a full colonoscopy, and found an area of severe inflammation with granulomas which is how we figured out he had crohn's. They put him on 120 mgs of solumedrol, but his crohn's did not respond to that at all. So, they added remicade and after 2 doses he was well enough to come home. It was quite an ordeal. He is still on remicade, Lialda and Canasa to control the crohn's.
This past September, he tested positive for c-diff again, but this time, the remicade kept the crohn's in check. What a huge difference that made. It made c-diff more of a nuisance than a major medical crisis. 2 weeks of vancomycin, and he was c-diff free again, and continues to remain c-diff free.
Vancomycin is extremely effective at fighting c-diff. I have not heard of any c-diff strains that are vancomycin resistant, thankfully. My husband usually started feeling better around day 3 of taking the vancomycin, when he was fighting c-diff. Of course any antibiotics themselves give my husband the runs, but he started feeling better in terms of lesser cramping, less frequent bowel movements, more mushy stool than complete watery diarrhea.
If you aren't responding to vancomycin, there's probably some level of crohn's going on. C-diff seems to aggravate crohn's quite a bit (at least this is true in my husband's case), and causes even mild cases of crohn's to have some really acute flare ups. I think without c-diff, my husband will have pretty mild crohn's. I think it is time to treat the crohn's aggressively as well. What meds are you on for the crohn's? My husband needed remicade, and it sounds like sickofitall needed remicade to control the crohn's flare up too.
Please talk to your GI about aggressively treating the crohn's - based on our experience, I strongly suspect that there is more than just c-diff causing problems; I suspect that crohn's is also flaring to some extent, because vancomycin really does a good job of treating c-diff infections.
I hope you get some answers soon, and start feeling better really soon.
Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Crohn's in Remission since June 2008
Reactive Arthritis Nov 2009
Currently c-diff free
Canasa (1gm), Lialda (4.8 gms), Remicade (6 weeks), Pred (5mg every other day)
Hoping to stop pred, and move remi back to every 8 weeks soon