I was on Methotrexate in November 09 for 6 weeks. It worsened my fistula, resulted in the induction of another fistula, and it dropped my WBC count massively (normal is 4-11...my WBCs dropped to 0.6). I had elevated liver enzymes aka liver damage, and I developed neutropenic fever, resulting in another admission into the hospital for 10 days....better than the 3 months I spent in the summer!
So, in conclusion, don't be scared of methotrexate, but DEFINITELY be weary of it. I was taking injections once a week. I took the shot at night before sleeping, and, yes, it made me feel very tired and flu-like for two or three days in a week. Make sure that you're having weekly blood tests done to check your CBC (complete blood count) and liver enzymes, tho methotrexate is known also to cause a whole bunch of other issues --- lung injury, liver injury, pancytopenia (dropping of all blood counts - white and red), rashes, and other stuff I can't really remember right now ---but DO NOT TAKE ANY ILL HEALTH LIGHTLY WHILE ON METHOTREXATE. not even a cold. I had a fever of 99.1 and ended up in the hospital after a nurse told me that that wasn't right.
A survivor of CAPS - Catastrophic Antiphospholipid Syndrome with infarcts in one kidney, spleen, liver, and intestines in July '09
Surgeries: cholecystectomy, partial enterectomy x 2 with surgical complication of EC fistula
Meds: Lovenox daily subQ injections, Metoprolol for hi BP
Previous Meds: Ritoxan, Methotrexate, Plasmapheresis, innumerable blood transfusions, and antibiotics galore.