Remicade.... Lupus?

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Regular Member

Date Joined Jun 2009
Total Posts : 46
   Posted 3/5/2010 4:42 PM (GMT -7)   
Hello my name is Kelly and I have Crohns April will make a year. I just started on Remicade I have had 4 treatments so far and it seems to be helping but my joints are hurting really bad so I went to see a doctor about them and he did some blood work. He said that I testest a 1/90 for Lupus and that I had lupus??? I read that u can get lupus like symptoms from remicade. I was worried. Has anyone every had this happen to them before. I dont go back to my GI until the 22nd of this month do I need 2 tell her and will I have to stop remicade....? I am really worried b/c remicade is the only thing that seems to work for me.... Could it be the remicade.... If anyone knows anything about this or could help me.... please write me..... Thank you so much!!

Regular Member

Date Joined Jan 2010
Total Posts : 448
   Posted 3/5/2010 5:27 PM (GMT -7)   
Lupus like syndrome can def. happen with Anti-TNF's.
Your symptoms Can and probably go away with stopping the remicade.

This DOESN'T mean that Cimzia or Humira Will cause these problems.

Humira is a Human Monoclonal antibody while Remicade is Chimeric. Or "mice" protein.

Remicade IS Alpha of the 3. Or leader or the best overall based on studies and Data and time.

But I can guarantee 110% you will find 10-15+ people on this forum who have had MAJOR success switching from Remicade, Working or NOT to humira or cimzia. Don't get discouraged. Be happy that The TNF's are working. All this means is that you built up antibodies. Maybe humira will work.!!

good luck.

Forum Moderator

Date Joined Nov 2003
Total Posts : 7122
   Posted 3/5/2010 5:35 PM (GMT -7)   
Yes, this happened to me. At the time, five years ago, it was thought that while a person could have positive lupus antibodies, there would be no other consequence of having these antibodies. Now it is known that some people that develop the antibodies can sometime get symptoms accompanying this. Joint pain and/or joint swelling, rashes, extreme fatigue, and sun sensitivity are just a few of the symptoms one can get.

I had my "incident" right after having an infusion that was a double dose. It was felt that if the dosage was returned to my original dosage, that the problem would resolve. I continued on Remicade for another 18 months with no further lupus symptoms. When Remicade was no longer controlling my symptoms, I was switched to Humira. Two and a half months after starting Humira I had a major reaction and became very ill. I was diagnosed with outright lupus. It took over ONE year for the symptoms to resolve and several months on prednisone and many more on Plaquenil.

Do you have a rheumatologist? I think it important that you see a rheumatologist and get him/her and your GI to make a recommendation as to what you should do.
Moderator Crohn's Disease  & Osteoarthritis Forums
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, asthma, severe allergy and a host of other medical problems.

Julia Hill
Veteran Member

Date Joined Mar 2008
Total Posts : 560
   Posted 3/5/2010 6:50 PM (GMT -7)   
I was on Remicade for 2 years or so when I developed remicade induced lupus. The joint pain jumps from one area to another. I remember I couldnt life my arm high enough to pour water into the coffee maker the pain was so intense. Next it went to my wrist and knees. It did go away, but only after I was on 25mg prednisone and MTX. Nothing else even touched it.

Please make a point of seeing a rheumy as I would hate to have you suffer needlessly.

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