METHOTREXATE CAN MAKE FISTULAS WORSE. use it with caution. it made my fistula worse. and caused neutropenic fever. it dropped all of my blood cells ---WBCs particularly and I had to be readmitted because of it. so watch your WBC count and your LFTs (liver function tests) --Bilirubin, AST, ALT (or SGOT/SGPT). It's a SUPER powerful chemotherapeutic agent so just be careful.
A survivor of CAPS - Catastrophic Antiphospholipid Syndrome with infarcts in one kidney, spleen, liver, and intestines in July '09
Surgeries: cholecystectomy, partial enterectomy x 2 with surgical complication of EC fistula
Meds: Lovenox daily subQ injections, Metoprolol for hi BP
Previous Meds: Ritoxan, Methotrexate, Plasmapheresis, innumerable blood transfusions, and antibiotics galore.