Hi. I'm taking Cimzia. I started taking it last November. I started with 2 shots, 400 mg each, every two weeks. They are injected in the abdomin or thigh subcutaneously. I do the shots myself at home. Now I'm on maintenance every 4 weeks. I have been recently diagnosed 9/09 with Chrons and UC and I'm new on here, so I don't have near the experience of most.
But, I was having all the horrible symtoms..horrible diarrhea, intense abdominal pain, etc, etc. It was so bad I could not take care of my kids. Now, I wouldn't say I'm in remission, but for about 3 weeks I feel really good. I can excercise, eat well, I have fairly normal bowel movements. I still have some abdominal pain, but not nearly as intense. For the last week leading up to the injections many of my symptoms return and I feel generally unwell. Some have reported that they have joint pain, but I've never experienced this. I haven't had any side effects as of yet that I know of. The thing I'm talking to my dtr right now is either supplementing that last week where I don't feel good or getting the injections closer together.
It's working for me. I haven't read that is is a "last resort (drug) as it would only be to treat the joint pain assoc with crohns." It is also used to treat Rheumatoid Arthritis. Cimzia blocks TNF-alpha (tumor necrosis factor-alpha) which is linked to triggering the inflamation associated with Chron's and RA. For more information see www.cimzia.com.
If you read the insert for Cimzia is does say that patients have reported either new conjestive heart failure, or can make conjestive heart failure you already have worse. You can't take if you have TB, and it is has a warning of patients who have developed Lymphoma, other fungi and conditions that have spread throughout the body and patients have died. But if you go and read about Remicade and other similar biological drugs..they carry the same warnings. I think this is related to the immune suppressing properties of biological drugs.
So, but there are risks in everthing. If you read too much about vaccines, you want to stop getting your kids vaccinated....so, have to weigh the risks and get your dtr to closly monitor you.
For me, it is a "miracle" drug because I feel so very much better. Can't even explain it is night and day before I started. I've only been on now for 5 mths, so I may have a different story later. I'll let you know!
Chron's at the distal ileum to the terminal ileum.
Diagnosed, September 2009.
Chronic Active Colitis, October 2009
Took Prednizone initally for about 2wks.
(40mg, tapered to 30, 20, to 10mg).
Been on Ciprofloxin and Metronidazole.
Took Lialda for about 4 wks in 11/2009.
Began Cimzia in Nov 10, 2009: 2 wk intervals (0, 2, 4, 6wks)
Curently taking Cimzia maintanence injections in the abdomin every 4 weeks, (2 shots- 400 mg each).
Taking iron supplements twice daily (325mg twice daily).
I'm allergic to Sulfasalazine and Bactrim.
Better, but would not characterise myself as in remission.