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Regular Member

Date Joined Aug 2004
Total Posts : 21
   Posted 3/17/2010 10:28 AM (GMT -7)   
Has anyone seen random side effects taking mercaptopurine/6mp? I have been on it for about 3 years and have just experience some normal stuff except for warts on my feet. I've been getting treatment for over a year but they keep coming back. I think it might be the 6mp. Anybody else get them?

Veteran Member

Date Joined May 2006
Total Posts : 1177
   Posted 3/17/2010 1:02 PM (GMT -7)   
My husband is not in 6-mp, but he has always had problems with warts. He needed to go the pulsed dye laser treatment route to remove plantar warts on his feet (treatment was about 1 year). He had tried freezing, the acid, going to a podiatrist and getting him to cut it out, etc. Only thing that has worked to get rid of them for him is the pulsed dye laser. My husband struggled with warts even before he was diagnosed with crohn's and put on remicade and prednisone.

I have noted that in general, people with crohn's seem to get more warts, and that they find it harder to get rid of the warts as well. It's almost like for people with Crohn's, their immune systems just don't notice that the warts are viral.

I think it may have to do with the underlying immune system malfunction that causes Crohn's that also makes you more susceptible to warts and makes it harder to get rid of them. I personally don't think it is specific to 6-mp. I don't have any hard facts for this theory, this is just based on my observation over time.

Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Crohn's in Remission since June 2008
C-diff recurrence Sep 2009
Reactive Arthritis Nov 2009
Currently c-diff free
Osteopenia of spine (Mar 2010)
Canasa (1gm), Lialda (4.8 gms), Remicade (8 weeks)
Currently In Remission

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 3/17/2010 1:24 PM (GMT -7)   
I have had this disease for almost 35 years and never suffered with warts. I have taken 6mp in the past and it never caused any issues like that for me. But not saying it couldn't happen though.
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Elite Member

Date Joined Jan 2010
Total Posts : 10092
   Posted 3/17/2010 1:50 PM (GMT -7)   
I got a few funky side-effects from 6-MP. Last summer, the skin on the back of my right hand became frazzled and gnarled. My right arm looked far more tanned than my left arm. Plus I got quite a few new moles. (All gone now, I think.) As well as looking unsightly, it also itched like mad. This puzzled me for weeks, then eventually the penny dropped; I'd spent a week in August driving around a lot with my dad. Hot weather. Sun coming in on the driver's side (the right in the UK). One time we got lost, pulled over, and I sat there for 10 minutes, right arm resting on the open window, mid afternoon sun beating down on it.

My right hand/arm would never have reacted like that normally and when I did some research on Healing Well I found out that 6-MP can cause photosensitivity reactions. This is the sort of stuff that doctors don't warn you about.

I did have a bad case of warts on my hands for two years when I was a teenager, but then they disappeared and I have never suffered from warts again.

Regular Member

Date Joined Aug 2004
Total Posts : 21
   Posted 3/17/2010 2:00 PM (GMT -7)   
I have been taking extra precautions with handling it and following my podiatrist instructions for over a year. I thought he was just trying to make a quick buck but new ones would appear. I thought last night that maybe it had something to do with the 6mp. I'm just gonna have to check with my GI eventually.

Veteran Member

Date Joined Jan 2007
Total Posts : 656
   Posted 3/17/2010 8:28 PM (GMT -7)   
No warts--but I did have to have a small basal cell carcinoma removed from right near my nose in December. Patients on 6MP (or other immunomodulators or immunosuppressants) have a higher incident of non-melanoma skin cancers than other people. Now I'm really scared--and trying to figure out which is worse, staying on the 6MP or getting off it. I've had no other side effects and take a relatively minimal dose of 6MP (50 mg/day), but I'm worried now.

Veteran Member

Date Joined Jan 2010
Total Posts : 794
   Posted 3/18/2010 12:35 PM (GMT -7)   
Interesting stuff!
As a much younger child my son had constant warts on his feet- we can't blame the Pentasa as his crohns not diagnosed until many years later .I am not sure if he still has them now (must ask) but at the time nothing we tried worked at removing them (over the counter remedies, freezing, podiatrist etc). I like PV's theory about the immune system although that makes me think that the genes on my side of the family could be responsible for his Crohn's (and warts) as I have had warts for years that will not go either. Something else to beat myself up about!!

Veteran Member

Date Joined Sep 2005
Total Posts : 517
   Posted 3/18/2010 12:45 PM (GMT -7)   
is believe that planters warts are from papillomavirus and there amazingly is no cure for this virus hence no cure for planters warts. I am planning on getting a biopsy on a wart from a dermatologist as the wart has yet to be identified as a wart.
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