.,...ok, I would like to suggest that you register at the LDN and IBD group at yahoo, several long time users are sitting there helping people out. Many of them have had a miserable start to LDN due to a few important facts:
LDN is now and then triggering an underlying candidiasis to overgrow, because (Dr. Mc Candless has explained this to the group, she's a nevrolog leading a research in Mali, Africa on LDN and Aids),
well, she has suggested that there's a shift between the Th1 and Th2 arm in the immune system when starting LDN, this leads to some bacterial overgrowth, and further on (up to 9 - 10 months) reduced symptom. Dr. Mc Candless is also a specialist in her field on autistic kids, and these kids often has gut issues. She learns the parents to avoid Gluten and Casein, and these kids are also using LDN, with great improvements. She has found that some people have to avoid: casein (milk products), gluten, soy and sugar.
Another problem might well be that you should take LDN as a transdermal cream, U.S. pharmacists like Ph.d. Dr. Skip at www.skipspharmacy.com and www.riverpharmacy.com are both compounding it. You could alway make a call to Dr. Skip. (a person that has been researching LDN for years). If you happen to have a sensitive stomach/gut, you will be better off taking LDN transdermal cream. It's easy to take and dose, just rub it on your inner arm wrist every night.
If you're having a hard time with LDN, get yourself tested and if candida IS a problem, LDN won't work untill you have got rid of it. Candidiasis is one the typical problems for many with Crohns, and many of us do not know we have it untill we take the stool tests. If you have candida, you'll find an increase in bathroom visits when using LDN. This person is experienced due to candida, lupus and LDN, read her blog her:
she's got a lot of knowledge.
Metabolism: If you want to try to reduce or increase your dose, don't use more than 6 mg for a long time as a maximum dose. Then gradually try to increase the dose up to 10 mg. Phd. dr. Jill Smith & al. have said that the max dose COULD be 10 mg for a smaller group, but the average group should stop at 4.5 mg. I personally now use 6.0 mg, and for the first time in more than 3 years I am totally symptom free. I am not sure what kind of metabolism I have, but I have just tried out different doses untill I landed at 6 mg as the best for me.
LDN is anyway a minor dose, at a homeopathic small level, and if you want to try out what suits you best, just do it. I think that lower than 1.5 mg and higher than 10 mg should be avoided.
If you know people with fibromyalgia, , asthma, ME (also called CFS, Cronique Fatique Syndrom), lupus, Crohns arthritis, reumathoid arthritis and MS, be nice and tell them to google LDN. LDN is regulating the immune system, if you want to try LDN it's really worth it. Just don't use it with narcotic pain killers.
Many of us will have some extraintestinal reactions when starting up with LDN. I personally had: joint pains, nauseau, a slight morning headache, and I got a rash. All this during the first 10 days. And of course, the vivid dreams. Most of them amusing. I had joint pain long before diagnosed with Crohns. In my hips, my shoulders, my knees. one week, and then: gone. /Bee
Post Edited (BeeSting) : 4/14/2010 8:38:26 AM (GMT-6)