Pentassa vs Apriso? c and UC?

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Veteran Member

Date Joined Jan 2010
Total Posts : 1120
   Posted 4/17/2010 8:17 AM (GMT -7)   
Update and question
Went to doc yesterday. Doc says current bloodtest shows normal, however she saw crohn's when biopsy was done during colonoscopy. So she is 100% I have crohns. I have been on Pentassa for 4 months and she says she is surprised I am still in pain. So she is changed to Apriso, and I am scheduling a pill cam. She thinks I might have UC also cause I have small bowel pain.
Does this make any sense to you? I am surprised she expected no symptoms after only 3 months on Pentassa. Also does anyone have experience with Apriso. Also I am sick but not as sick as many on this site, does it make any sense I might have both c and UC
Diagnosed March 3rd 2010, Kapidex 60mg, Pentasa 3000 mg, D 50,000 (weekly)

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 4/17/2010 8:26 AM (GMT -7)   
I think she is really saying you have Crohns Colitis. Thats when you have more Crohns in the large intestine vs only in the small. But since it is in both the small and large I think you have Crohns Colitis. Not familar with the Apriso, but I have found that I do better on Asacol vs Pentasa. Hopefully you will do better on the Apriso. Good luck!
Gail*Nanners* Co-Moderator for Crohns Disease & Anxiety/Panic
Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Regular Member

Date Joined Apr 2009
Total Posts : 71
   Posted 4/18/2010 1:57 PM (GMT -7)   
I don't have much experience with Pentasa (I stopped after a few weeks), but I'm on Apriso now (my doc also recommended it after finding inflammation in my small bowel).  Of all the 5-ASAs I've tried (Asacol, Pentasa and Lialda), I've personally had the best results with Apriso.  I noticed an improvement within 24 hours, which I thought was a fluke until I heard of a few others with similar results. 
The effectiveness of each of the 5-ASAs is dependent on where your inflammation is...with the exception of Lialda (which is a time release verion of Asacol), the key difference between the 5-ASAs is where in your intestine they are activated.  If you're not getting results from Pentasa, it might be worth giving Apriso a try, you can always switch back to Pentasa if you decide that it was helping more.
Good luck,
34 - Diagnosed with Crohn's in Nov. '05
Current Meds: Apriso, Canasa, Methotrexate, Pamine Forte, Aciphex, Domperidone, Folic Acid, Restasis, Plaquenil,  Xyzal, Zyrtec, Align, Calcium, Vitamin D, Centrum, Digestive Enzymes, Thera-tears Omega 3 Supplement, Co-Enzyme Q10
Gluten free since Aug. '03

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