Hi RoseAnnette.........I was diagnosed with CD without any positive biopsies. I have had so many tests that I couldn't possibly count them if my life depended on it. During the course of trying to get diagnosed, I went through about 6-7 Doctors - I couldn't find one that was aggressive enough, took me seriously, etc.......... Many Doctors will not make the Crohn's DX without positive biopsies from a colonoscopy or endoscopy but there are a lot of other ways to diagnose. I have had numerous other tests come back "normal" as well, including a pill cam.
They finally diagnosed me based on:
*Reaction to Crohn's Meds
*Blood Serologies - My ASCA scores and inflammatory markers are always 2-3 times the normal amount
*Several abnormal CT Scans that showed thickening of the bowel wall and stranding - keep in mind that I have also had several "Normal"scans
* A few partial small bowel obstructions from the inflammation
* A few other questionable test results
* Additional extra-intestinal symptoms
Crohn's DX in 2006 but sick for well over a year before that. Currently just started on Humira, Pred - 40mg (hoping to taper off of this soon), Phenergan 25gm prn, Percocet, Pentasa 500mg, Protonix 40mg and Lomotil, prn.
I live my life to the fullest, enjoy every day and am excited for the day when we will be able to say good-bye to CD and UC. I am becoming active in my local CCFA chapter and have found them to be a wonderful resource!