How bad does it have to get to start Humira?

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Regular Member

Date Joined Jul 2004
Total Posts : 422
   Posted 5/22/2010 5:56 PM (GMT -7)   
I just think of Humira as the end-all drug. If it doesn't work then surgery is next. Maybe that's not true but it's what I think. My GI wants to take me off Colazal & put me on Humira. My last colonoscopy showed active inflammation and evidently my CD has progressed since my last colonoscopy.

What are you opinions/experiences about going from a "simple" 5-ASA drug to Humira? Aren't there a lot of things inbetween I could try?

I admit I haven't felt great but I've felt much better than I did last year. I don't know...I'm just nervous about what to do...especially about going to an injection drug.
Diagnosed in October, 2004 at age 32 (misdiagnosed with IBS in 2002)
Current Rx's: Colazal (generic), Omeprazole (PRN), Librax, One-A-Day multivitamin, Probiotic, Omega-3 Fish Oil, Vitamin D, Cranberry pills; Slow Fe (PRN) 
Secondary conditions: swelling ankles, extreme fatigue, mouth ulcers, joint pain
Previous/occasional Rx's: Prednisone, Flagyl, Levaquin, Xifaxan, Carafate
4/7/09: Gall bladder removal laproscopic surgery (gall stones)

Becoming undone
Veteran Member

Date Joined Jul 2007
Total Posts : 927
   Posted 5/22/2010 6:31 PM (GMT -7)   
The newest and latest is that they want to use these medications right away to help you go into remission. Before, when they were just coming out, they would hold these medications in reserve, and had to be pretty severe in order to justify their use...but now, usually with a course or prednisone(which is temporary to reduce the inflammation), they go in with the TNF inhibitors...

I know it may sound scary (I was terrified when I had to start these meds too), but just get all the info you can and make and informed choice...ALL medications (even aspirin) have some sort of risk...

Honestly, the risks/side effects from prednisone are probably worse than those from Humira, but you have to be super careful on both.
"The earth laughs in flowers"

Veteran Member

Date Joined Aug 2007
Total Posts : 1202
   Posted 5/22/2010 7:04 PM (GMT -7)   
I would say that if your disease is progressing even though you are on the Colazol, then it's time to follow your doctor's advice. The TNF meds are a scary leap, but for the most part they are well-tolerated. Personally I think Humira is the best choice for a first time TNF med. Remicade, while having been around for a longer time, seems to put people into a position where their body quits responding due to developing antibodies to the medication itself. Humira does not carry that risk because it's made from human antibody instead of mouse (murine) antibodies. Besides, you can do the injection at home every two weeks => less time than remicade.

Good luck with your decision and whatever you choose know that the people on here are always willing to listen and offer support. Hang in there!
1 fistula, crohn's colitis, limited to large intestine
Compounded budesonide 3mg/daily, Cimzia, MTX . Dx Osteoporosis 10/08 started Forteo 1/27/09

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